DSPE-PEG600-DBCO
DSPE-PEG600-DBCO is a phospholipid PEG polymer that combines a hydrophobic phospholipid (DSPE), a hydrophilic polyethylene glycol spacer with a molecular weight of 600 Da, and a reactive click chemistry terminal group (DBCO). DSPE-PEG-DBCO migrates to lymph nodes via the endogenous albumin transport system, implants bioorthogonal DBCO docking sites, and enables the enrichment of azide-functionalized vesicles in lymph nodes mediated by click chemistry. DSPE-PEG-DBCO can be used in studies related to atherosclerosis.
For research use only. We do not sell to patients.
- Molecular Weight:600 (Average)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
DSPE-PEG2000-DBCO can be designed as the first dose (pretargeting anchor) of the two-component sonodynamic vaccine SenoVac: it efficiently migrates into lymph nodes via hitchhiking on endogenous albumin, pre-installs bioorthogonal DBCO docking sites in lymph nodes, and specifically and durably locks the azide-modified SCAV in lymph nodes through copper-free click chemistry when the second dose arrives[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
DSPE-PEG2000-DBCO (s.c.; single dose) achieves effective and sustained lymph node labeling, with fluorescence peaking at 24 hours and remaining detectable for up to 120 hours[1].
DSPE-PEG2000-DBCO (s.c.; administered prior to each vaccination dose) as part of the SenoVac platform reduces plaque senescent cell burden and attenuates atherosclerosis progression in high-fat diet-fed ApoE-/- mice[1].
DSPE-PEG2000-DBCO (s.c.; administered prior to N3-SCAVᴴᴿ) as part of the SenoVac platform reduces senescent cell burden across multiple organs in p16-tdTomato reporter mice, with efficacy enhanced by ultrasound stimulation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (male, 6-8-week-old)[1]
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Dosage:60 nmol
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Administration:s.c.; single dose
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Result:Exhibited approximately threefold higher lymph node fluorescence than DSPE-PEG-pretreated controls.
Showed strong fluorescence localized predominantly in draining lymph nodes, with moderate liver uptake and minimal signal in heart, spleen, lung, and kidney.
Chemical Information
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Molecular Weight 600 (Average)
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SMILES
CCCCCCCCCCCCCCCCCC(OC[C@](OC(CCCCCCCCCCCCCCCCC)=O)([H])COP(O)(OCCNC(OCCNC(CCCCC(N1C(C=CC=C2)=C2C#CC(C=CC=C3)=C3C1)=O)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DSPE-PEG600-DBCO Related Classifications
HY-W440835B Related Classifications
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