SM-102-d4
Based on 1 Customer Validation
SM-102-d4 is the deuterium labeled SM-102 (HY-134541). SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines.
For research use only. We do not sell to patients.
- Purity: 99.81%
- Formula: C44H83D4NO5
- Molecular Weight:714.19
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Isotope-Labeled Compounds Antibiotic Bacterial Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 2089251-47-6
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Appearance Viscous liquid
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Molecular Weight 714.19
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Formula C44H83D4NO5
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Color colorless
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SMILES
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(C([2H])([2H])C([2H])([2H])O)CCCCCC(OCCCCCCCCCCC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (140.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Escalona-Rayo O, et al. In vitro and in vivo evaluation of clinically-approved ionizable cationic lipids shows divergent results between mRNA transfection and vaccine efficacy. Biomed Pharmacother. 2023 Sep;165:115065. [Content Brief]
[2]. Cho HY, et al. Effective Perturbations on the Amplitude and Hysteresis of Erg-Mediated Potassium Current Caused by 1-Octylnonyl 8-[(2-hydroxyethyl)[6-oxo-6(undecyloxy)hexyl]amino]-octanoate (SM-102), a Cationic Lipid. Biomedicines. 2021 Oct 1;9(10):1367. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4002 mL | 7.0009 mL | 14.0019 mL | 35.0047 mL |
| 5 mM | 0.2800 mL | 1.4002 mL | 2.8004 mL | 7.0009 mL | |
| 10 mM | 0.1400 mL | 0.7001 mL | 1.4002 mL | 3.5005 mL | |
| 15 mM | 0.0933 mL | 0.4667 mL | 0.9335 mL | 2.3336 mL | |
| 20 mM | 0.0700 mL | 0.3500 mL | 0.7001 mL | 1.7502 mL | |
| 25 mM | 0.0560 mL | 0.2800 mL | 0.5601 mL | 1.4002 mL | |
| 30 mM | 0.0467 mL | 0.2334 mL | 0.4667 mL | 1.1668 mL | |
| 40 mM | 0.0350 mL | 0.1750 mL | 0.3500 mL | 0.8751 mL | |
| 50 mM | 0.0280 mL | 0.1400 mL | 0.2800 mL | 0.7001 mL | |
| 60 mM | 0.0233 mL | 0.1167 mL | 0.2334 mL | 0.5834 mL | |
| 80 mM | 0.0175 mL | 0.0875 mL | 0.1750 mL | 0.4376 mL | |
| 100 mM | 0.0140 mL | 0.0700 mL | 0.1400 mL | 0.3500 mL |
SM-102-d4 Related Classifications
HY-134541S6 Related Classifications
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