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Referencia número: HY-174485

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OVA mRNA (N1-Me-Pseudo UTP)

Name: OVA mRNA (N1-Me-Pseudo UTP)
Brand: MedChemExpress
SKU: HY-174485
Price: 300.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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OVA mRNA (N1-Me-Pseudo UTP) is an mRNA encoding chicken ovalbumin. The substitution with N1-Me-Pseudo UTP (m1Ψ) improves protein expression and reduces innate immune response. OVA mRNA binds to the STING-activating polymer PD18 and is encapsulated in optimized lipid nanoparticles to construct an mRNA vaccine platform (PD18 LNP). This platform not only enhances the lymphatic delivery efficiency and protein expression of mRNA, but also potently adjuvates immune responses via activating the STING pathway.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 95.2%

Almacenamiento:

-80°C

OVA mRNA (N1-Me-Pseudo UTP) Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

In Vitro

After OVA mRNA is successfully delivered to antigen-presenting cells (such as dendritic cells, DCs) and translated intracellularly to produce OVA protein, the protein is processed into short peptides (such as SIINFEKL) and presented on the cell surface via major histocompatibility complex class I molecules. This process activates antigen-specific CD8⁺ T cells, thereby triggering a cellular immune response against target cells expressing the antigen.^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Appearance Liquid
Color Colorless to light yellow
Envío

Shipping with dry ice.
Almacenamiento

-80°C

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (264 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Zhang M, et al. STING-Activating Polymers Boost Lymphatic Delivery of mRNA Vaccine to Potentiate Cancer Immunotherapy. Adv Mater. 2025;37(10):e2412654.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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OVA mRNA (N1-Me-Pseudo UTP)

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Actividad biológica
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- In Vitro
Chemical Information
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OVA mRNA (N1-Me-Pseudo UTP)

Actividad biológica

Descripciòn

In Vitro

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

OVA mRNA (N1-Me-Pseudo UTP) Related Classifications

HY-174485 Related Classifications

Bioz

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