mPEG750-amine
Based on 1 Customer Validation
mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folate receptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 90.0%
- CAS. Nr.: 80506-64-5
- Formel: (C2H4O)nC3H9NO
- Molecular Weight:750 (Average)
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Speicherung:
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Ad-PVA-PEG750, synthesized from mPEG750-amine via CDI activation reaction with Ad-PVA (stable for >5 days at pH=7, and 48 hours at pH=4), remains stable in a physiological environment at pH=7, but undergoes degradation via acetal bond cleavage under acidic conditions at pH=4, confirming its acid-responsive nature[2].
Ad-PVA-PEG750 synthesized from mPEG750-amine (forming complexes with cationic β-CD derivatives and pDNA at an N:P ratio ≥5) effectively concentrates pDNA. Compared to cationic β-CD alone, complete pDNA condensation and inhibition of its migration in agarose gel can be achieved at a lower N:P ratio[2].
The complex formed by Ad-PVA-PEG750 synthesized from mPEG750-amine and cationic β-CD exhibits 1000 times lower cytotoxicity to HeLa cells than 25 kDa bPEI, significantly reducing the cytotoxicity of the gene carrier[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
It can also be used to evaluate the effects of mPEG-750 modified silicone nanoparticles on the mouse hematopoietic system (hemolysis, coagulation function)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 80506-64-5
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Appearance Oil
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Molecular Weight 750 (Average)
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Formel (C2H4O)nC3H9NO
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Color Off-white to light yellow
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SMILES
COCCOCCN.[n]
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Synonyms
mPEG750-NH2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Reinheit & Dokumentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
mPEG750-amine Related Classifications
HY-155882 Related Classifications
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