1. Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. STING
    Endogenous Metabolite
  3. Cyclic-di-GMP sodium

Cyclic-di-GMP sodium  (Synonyms: c-di-GMP sodium; cyclic diguanylate sodium; 5GP-5GP sodium)

Cat. No.: HY-107780A
Handling Instructions

Cyclic-di-GMP sodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP sodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP sodium can be used in cancer research.

For research use only. We do not sell to patients.

Cyclic-di-GMP sodium Chemical Structure

Cyclic-di-GMP sodium Chemical Structure

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Description

Cyclic-di-GMP sodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP sodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP sodium can be used in cancer research[1][2][3][4].

IC50 & Target
In Vitro

Cyclic-di-GMP sodium (0.5-50 µM; 5 days) inhibits proliferation of human colon cancer cells[1].
Cyclic-di-GMP sodium (0.5-50 µM; 5 days) specifically elevates CD4 expression in Jurkat cells[2].
Cyclic-di-GMP sodium (0.5-50 µM; 5 days) induces cell cycle arrest at the S-phase in Jurkat cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: H508 cells
Concentration: 0.5-50 µM
Incubation Time: 5 days
Result: Reduced basal H508 cell proliferation by approx 15%, even inhibited acetylcholine- and EGF-induced cell proliferation.

Cell Viability Assay[2]

Cell Line: Jurkat cells
Concentration: 50 µM
Incubation Time: 24 h
Result: Specifically induced of CD4 (no effect on the expression of CD8), with a 6.3-fold upregulation over control and in a dose-dependent manner.

Cell Cycle Analysis[2]

Cell Line: Jurkat cells
Concentration: 50 µM
Incubation Time: 24 h
Result: Increased the percentage of cells in S-phase by 79%, with almost complete disappearance of G2/M-phase cells which decreased by 93%.
In Vivo

Cyclic-di-GMP sodium (100 µg/per; i.v.; two sequential vaccinations 9 days apart) enhances TriVax-induced immune responses to melanoma in mice and further increased the anti-tumor effects of TriVax[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (B6) mice (8- to 10-week-old)[3].
Dosage: 100 µg/per
Administration: Intravenous injection; two sequential vaccinations 9 days apart; combine with TriVax.
Result: Significantly higher numbers of antigen-specific CD8 T cells when combined with TriVax. (TriVax consisted of a mixture of 120 μg Pam-hgp100, 100 µg hgp100 or 100 µg Ova, 50 or 25 μg anti-CD40 antibody, and 25 μg Poly-IC).
Enhanced the anti-tumor activity of TriVax.
Formula

C20H24N10NaO14P2

SMILES

O[[email protected]@H]([[email protected]](N1C=NC2=C1N=C(N)NC2=O)O3)[[email protected]](OP(O)(OC[[email protected]@H]4[[email protected]]([[email protected]]([[email protected]](N5C=NC6=C5N=C(N)NC6=O)O4)O)O7)=O)[[email protected]]3COP7(O)=O.[Na].[x]

Structure Classification
Source

bacterial species

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Cyclic-di-GMP sodium
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HY-107780A
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