2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. TL8-506

TL8-506 is a specific TLR8 agonist with an EC50 of 30 nM. TL8-506 can be used for the research of tuberculosis and autoimmune diseases.

For research use only. We do not sell to patients.

TL8-506 Chemical Structure

TL8-506 Chemical Structure

CAS No. : 1268163-15-0

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5 mg USD 350 In-stock
10 mg USD 600 In-stock
25 mg USD 1250 In-stock
50 mg USD 1950 In-stock
100 mg USD 3200 In-stock
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Based on 1 publication(s) in Google Scholar

TL8-506 Related Antibodies

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Description

TL8-506 is a specific TLR8 agonist with an EC50 of 30 nM. TL8-506 can be used for the research of tuberculosis and autoimmune diseases[1].

Molecular Weight

331.37

Formula

C20H17N3O2
CAS No.
Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C(C1=CC2=CC=C(C3=CC=CC(C#N)=C3)C=C2N=C(N)C1)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (37.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0178 mL 15.0889 mL 30.1777 mL
5 mM 0.6036 mL 3.0178 mL 6.0355 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0178 mL 15.0889 mL 30.1777 mL 75.4444 mL
5 mM 0.6036 mL 3.0178 mL 6.0355 mL 15.0889 mL
10 mM 0.3018 mL 1.5089 mL 3.0178 mL 7.5444 mL
15 mM 0.2012 mL 1.0059 mL 2.0118 mL 5.0296 mL
20 mM 0.1509 mL 0.7544 mL 1.5089 mL 3.7722 mL
25 mM 0.1207 mL 0.6036 mL 1.2071 mL 3.0178 mL
30 mM 0.1006 mL 0.5030 mL 1.0059 mL 2.5148 mL
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TL8-506 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TL8-5061268163-15-0Toll-like Receptor (TLR)specific TLR8 agonisttuberculosisautoimmune diseasesInhibitorinhibitorinhibit

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