TL8-506 (GMP) is TL8-506 (HY-20457) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. TL8-506 is a specific TLR8 agonist with an EC50 of 30?nM. TL8-506 has immunomodulatory effects and can be used in the study of tuberculosis and cancer immunotherapy.
For research use only. We do not sell to patients.
- CAS No.: 1268163-15-0
- Formula: C20H17N3O2
- Molecular Weight:331.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TLR8 30 nM (EC50) |
TL8-506 (1 μM; 18 h) can activate dendritic cells in blood and tumors, induce the secretion of pro-inflammatory cytokines and chemokines, and promote the activation and recruitment of T cells (TL8-506 synergized with IFN-γ or Poly(I:C))[1].
TL8-506 can specifically activate TLR8 in vitro in TLR8 transgenic mouse bone marrow cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mtb H37Rv treated female TLR8 transgenic mice aged 6 weeks old[2]
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Dosage:Twice, four weeks apart
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Administration:Intramuscular injection (i.m.); TL8-506 was in form of ESAT6-Alum-TL8-506.
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Result:Provided better protection against Mtb challenge compared to ESAT6-Alum. The CFU in the lungs of mice treated with ESAT6-Alum-TL8-506 was significantly lower than that in the ESAT6-Alum group.
Significantly lowered bacterial load in the lungs and livers of mice.
Significantly ameliorated the tuberculous pneumonia and alveolitis and reduced the numbers and the area of granulomas.
Significantly increased the proportion of central memory CD8+ T cells.
Chemical Information
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CAS No. 1268163-15-0
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Molecular Weight 331.37
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Formula C20H17N3O2
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SMILES
O=C(C1=CC2=CC=C(C3=CC=CC(C#N)=C3)C=C2N=C(N)C1)OCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Jun Tang, et al. Toll-Like Receptor 8 Agonist Strengthens the Protective Efficacy of ESAT-6 Immunization to Mycobacterium tuberculosis Infection. Front Immunol. 2018 Jan 24;8:1972. [Content Brief]
[2]. He M, S, et al. Combinations of Toll-like receptor 8 agonist TL8-506 activate human tumor-derived dendritic cells. J Immunother Cancer. 2022 Jun;10(6):e004268. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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