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Cat. No.: HY-156985

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Lipid AX4

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Lipid AX4 is an ionizable cationic lipid that can be used to construct lipid nanoparticles (LNPs) for in vivo delivery of nucleic acids (e.g., mRNA, circRNA).

For research use only. We do not sell to patients.

Purity: 98.5%
CAS No.: 2735814-23-8
Formula: C₈₃H₁₅₅N₃O₁₆
Molecular Weight:1451.13

Storage:

Solution, -20°C, 2 years

Lipid AX4 Chemical Structure

CAS No.: 2735814-23-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Lipid AX4 is an ionizable cationic lipid that can be used to construct lipid nanoparticles (LNPs) for in vivo delivery of nucleic acids (e.g., mRNA, circRNA).

In Vitro

Lipid AX4 encapsulates circular mRNA (cmRNA) encoding the RBD trimer of the SARS-CoV-2 Delta variant to form the Delta variant circular mRNA vaccine cmRNA-1130^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2735814-23-8
Appearance Liquid
Molecular Weight 1451.13
Formula C₈₃H₁₅₅N₃O₁₆
Color Colorless to light yellow
SMILES

O=C(CCN(CCCN(CCCN(CCC(OCCCCOC(C(CCCCCC)CCCC)=O)=O)CCC(OCCCCOC(C(CCCCCC)CCCC)=O)=O)C)CCC(OCCCCOC(C(CCCCCC)CCCC)=O)=O)OCCCCOC(C(CCCCCC)CCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huang, K., et al. (2022). Delivery of circular mRNA via degradable lipid nanoparticles against SARS-CoV-2 delta variant. BioRxiv, 2022-05.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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