1. GPCR/G Protein
  2. Glucocorticoid Receptor
  3. Budesonide

Budesonide 

Cat. No.: HY-13580 Purity: 99.66%
Handling Instructions

Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma.

For research use only. We do not sell to patients.

Budesonide Chemical Structure

Budesonide Chemical Structure

CAS No. : 51333-22-3

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10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
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200 mg USD 103 In-stock
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500 mg USD 234 In-stock
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Based on 2 publication(s) in Google Scholar

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Description

Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma[1][2][3].

In Vitro

Budesonide is selective for human glucocorticoid receptor (hGR; EC50=45.7 pM) over mineralocorticoid receptors (EC50=7,620 pM) in CV-1 cells[1].
Budesonide (30 min prior to LPS) suppresses the activation of the NLRP3 inflammasome by LPS (100 ng/mL) plus ATP (5 mM) in macrophages (RAW 264.7 cells)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Budesonide (2.0 mg/kg; orally via their diet; at 2, 7 and 21 days prior to killing) decreases the size of lung tumors[3].
Budesonide (0.5 mg/kg; intranasal administration 1 h before LPS injection (5 mg/kg)) pretreatment dramatically attenuates pathological injury and reduces pathological scores in mice with ALI in adult male C57BL/6 mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female strain A/J mice at 8 weeks of age[3]
Dosage: 2.0 mg/kg
Administration: Orally via their diet; at 2, 7 and 21 days prior to killing (27 weeks)
Result: Reduced the size of the lung tumors after 2 days and rapidly decreased the size of lung tumors, reversed DNA hypomethylation and modulated mRNA expression of genes.
Clinical Trial
Molecular Weight

430.53

Formula

C₂₅H₃₄O₆

CAS No.

51333-22-3

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 215 mg/mL (499.38 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3227 mL 11.6136 mL 23.2272 mL
5 mM 0.4645 mL 2.3227 mL 4.6454 mL
10 mM 0.2323 mL 1.1614 mL 2.3227 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.83 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.83 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.83 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BudesonideGlucocorticoid ReceptorinhaledglucocorticalsteroidorallylungtumorsDNAhypomethylationmRNAanti-inflammatoryasthmaInhibitorinhibitorinhibit

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Product Name:
Budesonide
Cat. No.:
HY-13580
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