1. GPCR/G Protein
  2. Glucocorticoid Receptor
  3. Mometasone furoate

Mometasone furoate (Synonyms: Sch32088)

Cat. No.: HY-13693 Purity: 99.99%
Handling Instructions

Mometasone furoate (Sch32088) is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic activity. Mometasone furoate acts as a corticosteroid agent and used for topical applications in chronic skin eczema and airway inflammation management of asthma in vivo

For research use only. We do not sell to patients.

Mometasone furoate Chemical Structure

Mometasone furoate Chemical Structure

CAS No. : 83919-23-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg USD 96 In-stock
Estimated Time of Arrival: December 31
200 mg USD 156 In-stock
Estimated Time of Arrival: December 31
500 mg USD 228 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Mometasone furoate

    Mometasone furoate purchased from MCE. Usage Cited in: Hematology. 2018 Sep;23(8):478-485.

    MF (Mometasone furoate) inhibits CCRF-CEM cell invasion and migration. (The images represent that the invasive and migrated CCRF-CEM cells are stained by crystal violet.

    Mometasone furoate purchased from MCE. Usage Cited in: Hematology. 2018 Sep;23(8):478-485.

    MF (Mometasone furoate) induces CCRF-CEM cell apoptosis. Western blot analysis of CCRF-CEM cells treated with MF for 24 h.

    Mometasone furoate purchased from MCE. Usage Cited in: Hematology. 2018 Sep;23(8):478-485.

    Effects of MF (Mometasone furoate) on the PI3K signaling pathway in CCRF-CEM cells. Expression levels of AKT, p-AKT, mTOR, p-mTOR, p70S6K, Cyclin D1 and VEGF are measured in the CCRF-CEM cells treatment with MF using western blot analysis.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Mometasone furoate (Sch32088) is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic activity. Mometasone furoate acts as a corticosteroid agent and used for topical applications in chronic skin eczema and airway inflammation management of asthma in vivo[1]

    IC50 & Target

    IC50: Glucocorticoid Receptor

    In Vitro

    Mometasone furoate binds to a glucocorticoid receptor causes conformational changes in the receptor, separation from chaperones, and the receptor moves to the nucleus[1].
    Mometasone furoate (0.1-10 μM; 2h before LPS stimulation) strongly inhibits LPS-stimulated nitrite production in a concentration-dependent manner in J774 macrophages, The IC50 value is 0.00024 μM for Mometasone furoate in J774 cells[1].
    Mometasone furoate (0.1-10 μM; 2h before LPS stimulation) is more potent than DEX, it significantly inhibits iNOS expression at a 0.01 µM concentration whereas Dex became active at 0.1 µM. Additionally, the inhibition of cox-2 protein expression at 0.01 μM is 79% for Mometasone furoate and 39% for Dex[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    521.43

    Formula

    C₂₇H₃₀Cl₂O₆

    CAS No.

    83919-23-7

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (95.89 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9178 mL 9.5890 mL 19.1780 mL
    5 mM 0.3836 mL 1.9178 mL 3.8356 mL
    10 mM 0.1918 mL 0.9589 mL 1.9178 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (4.79 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.79 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Mometasone furoateSch32088Sch 32088Sch-32088Glucocorticoid Receptorsteroidskin corticosteroidhay feverasthmaAnti-inflammatoryeczemaGCInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

     

    Salutation

    Applicant Name *

     

    Email address *

    Phone number *

     

    Organization name *

    Department *

     

    Requested quantity *

    Country or Region *

         

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Mometasone furoate
    Cat. No.:
    HY-13693
    Quantity:
    MCE Japan Authorized Agent: