2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor Protein Tyrosine Kinase/RTK
  3. Glucocorticoid Receptor FGFR
  4. Triamcinolone acetonide

Triamcinolone acetonide inhibits basic fibroblast growth factor (bFGF) induced proliferation of retinal endothelial cells. Triamcinolone acetonide reduces chondrocyte viability and leads to cartilage destruction. Triamcinolone acetonide activates macrophage with anti-inflammatory characteristics. Triamcinolone acetonide can be used in the study of diseases such as atopic dermatitis.

For research use only. We do not sell to patients.

CAS No. : 76-25-5

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
500 mg In-stock
1 g In-stock
5 g In-stock
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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Triamcinolone acetonide:

Triamcinolone acetonide Related Antibodies

Top Publications Citing Use of Products

    Triamcinolone acetonide purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta Mol Cell Res. 2025 Jun 10:120003.  [Abstract]

    Triamcinolone acetonide (TA) (0.05 mL/g) treatment reduced dermal thickness and epidermal hyperplasia, decreased cell numbers, increased the number of dermal appendages, and significantly decreased the scar cross-sectional area in HS mice.

    Triamcinolone acetonide purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta Mol Cell Res. 2025 Jun 10:120003.  [Abstract]

    Triamcinolone acetonide (TA) (0.05 mL/g) reduced collagen deposition in the scars and diminished the fibrotic area at the injury site in HS mice.

    Triamcinolone acetonide purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta Mol Cell Res. 2025 Jun 10:120003.  [Abstract]

    Triamcinolone acetonide (TA) (0.05 mL/g) significantly reduced the relative fluorescence intensity of α-SMA, a marker of myofibroblasts and indicative of collagen matrix contraction ability in the scar tissues of HS mice.

    Triamcinolone acetonide purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta Mol Cell Res. 2025 Jun 10:120003.  [Abstract]

    Triamcinolone acetonide (TA) (0.05 mL/g) significantly reduced the levels of CD31 and Ki67, marker proteins of angiogenesis and proliferation, in the scar tissue of HS mice.

    Triamcinolone acetonide purchased from MedChemExpress. Usage Cited in: Ghent university

    Simulation output of Triamcinolone acetonide (TA) (4 mg; i.v.; 2500 h) ocular rabbit model. Observed (squares) and predicted (solid line) values in VH (green), AH (red), and plasma (blue). Concentrations in ng/mL.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Triamcinolone acetonide inhibits basic fibroblast growth factor (bFGF) induced proliferation of retinal endothelial cells. Triamcinolone acetonide reduces chondrocyte viability and leads to cartilage destruction. Triamcinolone acetonide activates macrophage with anti-inflammatory characteristics. Triamcinolone acetonide can be used in the study of diseases such as atopic dermatitis[1][2][3][4].

    Cellular Effect
    Cell Line Type Value Description References
    NIH3T3 IC50
    2.5 μM
    Compound: 2 ; Triamcinolone acetonide (TA)
    Inhibition of NIH 3T3 cell growth required to induce 50% of maximum response using antiproliferative assay
    Inhibition of NIH 3T3 cell growth required to induce 50% of maximum response using antiproliferative assay
    		[PMID: 11855992]
    In Vitro

    Triamcinolone acetonide (0.05-3 mg/mL, 48-60 h) decreases the proliferation of BRECs with increasing concentration[1].
    Triamcinolone acetonide (0.04-5 mg/mL, 24 h) reduces chondrocyte viability in both normal and osteoarthritic (OA) chondrocytes in a concentration-dependent manner[2].
    Triamcinolone acetonide (0.04-5 mg/mL, 24 h) increases the severity of cartilage structural damage, chondrocyte loss and cluster formation, and proteoglycan loss in OA cartilage[2].
    Triamcinolone acetonide (100 nM, 7 days) strongly induces monocyte differentiation towards an M2 and anti-inflammatory macrophage phenotype[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Triamcinolone acetonide Related Antibodies

    Cell Viability Assay[2]

    Cell Line: Chondrocyte
    Concentration: 0.04, 0.08, 0.16, 0.31, 0.63, 1.25, 2.5, and 5 mg/ml
    Incubation Time: 24 h
    Result: Reduced cell viability with the value of IC50 was 2.23 mg/mL in normal chondrocytes and 1.14 mg/mL in OA chondrocytes.
    In Vivo

    Triamcinolone acetonide (1.43 mg/mL, Intraperitoneal injection, once a week for 6-12 weeks) enhances folate receptor beta (FRβ)-related macrophage activation and fully prevents osteophyte development in an in vivo rat model of Osteoarthritis[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Severe OA rat model [3]
    Dosage: 1.43 mg/mL
    Administration: Intraperitoneal injection (i.p.)
    Result: Decreased body weight during OA induction.
    Showed more macrophage activation and minimal or no osteophyte formation when injected knee joints.
    Clinical Trial
    Molecular Weight

    434.50

    Formula

    C24H31FO6
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OCC([C@]12[C@@]3([C@@]([C@@]4([H])[C@]([C@H](C3)O)([C@@]5(C(CC4)=CC(C=C5)=O)C)F)([H])C[C@@]1([H])OC(C)(O2)C)C)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (115.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3015 mL 11.5075 mL 23.0150 mL
    5 mM 0.4603 mL 2.3015 mL 4.6030 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (4.79 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (4.79 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    g

    Dosing volume
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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
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    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.95%

    SDS (419 KB)

    COA (257 KB) HNMR (299 KB) RP-HPLC (245 KB) MS (69 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.3015 mL 11.5075 mL 23.0150 mL 57.5374 mL
    5 mM 0.4603 mL 2.3015 mL 4.6030 mL 11.5075 mL
    10 mM 0.2301 mL 1.1507 mL 2.3015 mL 5.7537 mL
    15 mM 0.1534 mL 0.7672 mL 1.5343 mL 3.8358 mL
    20 mM 0.1151 mL 0.5754 mL 1.1507 mL 2.8769 mL
    25 mM 0.0921 mL 0.4603 mL 0.9206 mL 2.3015 mL
    30 mM 0.0767 mL 0.3836 mL 0.7672 mL 1.9179 mL
    40 mM 0.0575 mL 0.2877 mL 0.5754 mL 1.4384 mL
    50 mM 0.0460 mL 0.2301 mL 0.4603 mL 1.1507 mL
    60 mM 0.0384 mL 0.1918 mL 0.3836 mL 0.9590 mL
    80 mM 0.0288 mL 0.1438 mL 0.2877 mL 0.7192 mL
    100 mM 0.0230 mL 0.1151 mL 0.2301 mL 0.5754 mL
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    Triamcinolone acetonide Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Triamcinolone acetonide76-25-5Glucocorticoid ReceptorFGFRFibroblast growth factor receptorBovine retinal endothelial cells (BRECs)ChondrocytesOsteoarthriticanti-inflammatory macrophageM2Inhibitorinhibitorinhibit

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