1. GPCR/G Protein
  2. Glucocorticoid Receptor
  3. Ciclesonide

Ciclesonide (Synonyms: RPR251526)

Cat. No.: HY-B0625 Purity: 99.45%
Handling Instructions

Ciclesonide (RPR251526) is a glucocorticoid with an potent anti-inflammatory activity. Ciclesonide can be used for asthma research.

For research use only. We do not sell to patients.

Ciclesonide Chemical Structure

Ciclesonide Chemical Structure

CAS No. : 126544-47-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 198 In-stock
Estimated Time of Arrival: December 31
50 mg USD 180 In-stock
Estimated Time of Arrival: December 31
100 mg USD 295 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Ciclesonide (RPR251526) is a glucocorticoid with an potent anti-inflammatory activity. Ciclesonide can be used for asthma research[1].

In Vitro

Ciclesonide, the parent compound, undergoes hydrolysis by ester cleavage at the C21 position to the active metabolite, desisobutyryl-ciclesonide (des-CIC), followed by reversible formation of fatty acid esters within the lung cells. Ciclesonide (5 μM) is rapidly hydrolyzed by normal human bronchial epithelial (NHBE) cells (approximately 30% conversion at 4h), with almost complete conversion by 24 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

540.69

Formula

C₃₂H₄₄O₇

CAS No.

126544-47-6

SMILES

O=C([[email protected]]([[email protected]@]1([H])C[[email protected]@]2([H])[[email protected]@](CCC3=CC4=O)([H])[[email protected]]([[email protected]]3(C=C4)C)([H])[[email protected]@H](O)C5)(O[[email protected]](C6CCCCC6)O1)[[email protected]]25C)COC(C(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (92.47 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8495 mL 9.2474 mL 18.4949 mL
5 mM 0.3699 mL 1.8495 mL 3.6990 mL
10 mM 0.1849 mL 0.9247 mL 1.8495 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.62 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.62 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.45%

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Keywords:

CiclesonideRPR251526RPR 251526RPR-251526Glucocorticoid ReceptorInhibitorinhibitorinhibit

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Ciclesonide
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HY-B0625
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