1. GPCR/G Protein
    Autophagy
    Anti-infection
  2. Glucocorticoid Receptor
    Autophagy
    SARS-CoV
  3. Methylprednisolone

Methylprednisolone (Synonyms: U 7532)

Cat. No.: HY-B0260 Purity: 99.67%
Handling Instructions

Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels.

For research use only. We do not sell to patients.

Methylprednisolone Chemical Structure

Methylprednisolone Chemical Structure

CAS No. : 83-43-2

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10 mM * 1  mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
500 mg USD 110 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Methylprednisolone:

Top Publications Citing Use of Products

    Methylprednisolone purchased from MCE. Usage Cited in: Int J Biol Sci 2020; 16(13):2382-2391.

    After treatment of GES-1 cells with 100 nM glucocorticoids or chemicals for 48 h, the protein expression levels of ACE2 is examined. Compared to the blank control, Methylprednisolone reveals an activating effect on ACE2 expression.
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    Description

    Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3].

    IC50 & Target

    Glucocorticoid Receptor

    In Vitro

    Methylprednisolone is typically used for its anti-inflammatory effects. Common uses include arthritis therapy and short-term treatment of bronchial inflammation or acute bronchitis due to various respiratory diseases. Methylprednisolone is used both in the treatment of acute periods and long-term management of autoimmune diseases, most notably systemic lupus erythematosus. It is also used for vestibular neuritis [1]. After six months the patients who were treated with methylprednisolone within eight hours of their injury had significant improvement as compared with those given placebo in motor function (neurologic change scores of 16.0 and 11.2, respectively; P = 0.03) and sensation to pinprick (change scores of 11.4 and 6.6; P = 0.02) and touch (change scores, 8.9 and 4.3; P = 0.03). Benefit from methylprednisolone was seen in patients whose injuries were initially evaluated as neurologically complete, as well as in those believed to have incomplete lesions [2].

    Clinical Trial
    Molecular Weight

    374.47

    Formula

    C₂₂H₃₀O₅

    CAS No.

    83-43-2

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (267.04 mM)

    H2O : < 0.1 mg/mL (insoluble)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6704 mL 13.3522 mL 26.7044 mL
    5 mM 0.5341 mL 2.6704 mL 5.3409 mL
    10 mM 0.2670 mL 1.3352 mL 2.6704 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (6.68 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (6.68 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (6.68 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    MethylprednisoloneU 7532U7532U-7532Glucocorticoid ReceptorAutophagySARS-CoVSARS coronavirusInhibitorinhibitorinhibit

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