1. GPCR/G Protein
    Autophagy
  2. Glucocorticoid Receptor
    Autophagy
  3. Methylprednisolone

Methylprednisolone (Synonyms: U 7532)

Cat. No.: HY-B0260 Purity: 99.67%
Handling Instructions

Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties.

For research use only. We do not sell to patients.

Methylprednisolone Chemical Structure

Methylprednisolone Chemical Structure

CAS No. : 83-43-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
500 mg USD 110 In-stock
Estimated Time of Arrival: December 31
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Other Forms of Methylprednisolone:

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Description

Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Target: Glucocorticoid Receptor Methylprednisolone is typically used for its anti-inflammatory effects. Common uses include arthritis therapy and short-term treatment of bronchial inflammation or acute bronchitis due to various respiratory diseases. Methylprednisolone is used both in the treatment of acute periods and long-term management of autoimmune diseases, most notably systemic lupus erythematosus. It is also used for vestibular neuritis [1]. After six months the patients who were treated with methylprednisolone within eight hours of their injury had significant improvement as compared with those given placebo in motor function (neurologic change scores of 16.0 and 11.2, respectively; P = 0.03) and sensation to pinprick (change scores of 11.4 and 6.6; P = 0.02) and touch (change scores, 8.9 and 4.3; P = 0.03). Benefit from methylprednisolone was seen in patients whose injuries were initially evaluated as neurologically complete, as well as in those believed to have incomplete lesions [2].

Clinical Trial
Storage

4°C, protect from light

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (267.04 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6704 mL 13.3522 mL 26.7044 mL
5 mM 0.5341 mL 2.6704 mL 5.3409 mL
10 mM 0.2670 mL 1.3352 mL 2.6704 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.68 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.68 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.68 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

374.47

Formula

C₂₂H₃₀O₅

CAS No.

83-43-2

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Methylprednisolone
Cat. No.:
HY-B0260
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Methylprednisolone

Cat. No.: HY-B0260