XJB-5-131
Based on 6 publication(s) in Google Scholar
XJB-5-131 is a mitochondria-targeted ROS and electron scavenger. XJB-5-131 is a bi-functional antioxidant that comprises a radical scavenger. XJB-5-131 is a synthetic antioxidant that targets mitochondria. XJB-5-131 is an effective ionizing irradiation protector and mitigator of cord blood mononuclear cells (CB MNCs).
For research use only. We do not sell to patients.
- Purity: 99.15%
- CAS No.: 866404-31-1
- Formula: C53H81N7O9
- Molecular Weight:960.25
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) XJB-5-131
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Biological Activity
XJB-5-131 also ameliorates hemorrhagic shock (HS)-induced activation of the pro-apoptotic enzymes, caspases 3 and 7, in ileal mucosa[1].
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XJB-5-131 reduces apoptosis and enhances cell survival in mouse embryonic cells?in vitro[2].
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XJB-5-131 is a radiation protector for colony-forming unit-granulocyte macrophage (CFU-GM). XJB-5-131 is an effective mitigator when added after irradiation[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Low density mononuclear cells (MNC)
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Concentration:10 μM
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Incubation Time:Added to cells one hour before irradiation or immediately after irradiation
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Result:Was a protector when given before irradiation as shown by an increase in the D0 to 1.93±0.13 for CFU-GM with XJB-5-131.
? Intravenous treatment with XJB-5-131 (2 μmol/kg) significantly prolongs the survival of rats subjected to profound blood loss (33.5 mL/kg) despite administration of only a minimal volume of crystalloid solution (2.8 mL/kg) and the absence of blood transfusion[1].
? XJB-5-131 reduces oxidative damage to mitochondrial DNA, maintains mitochondrial DNA copy number, suppresses motor decline and weight loss, enhances neuronal survival, and improves mitochondrial function. XJB-5-131 significantly suppresses the disease phenotypes and improves mitochondrial function in a mouse model of Huntington’s disease (HD) [2].
XJB-5-131 (1 mg/kg; intraperitoneally injected; three times a week up to 57 weeks) suppresses decline of weight loss and motor function in a mouse model of HD[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male specific pathogen-free Sprague-Dawley rats, weighing 150 to 250 g[1]
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Dosage:2 μmol/kg
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Administration:Administered intravenously using a syringe pump
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Result:The rats treated with XJB-5-131 survived significantly longer (P < 0.01). Three of six survived for longer than 3 hours after completion of the hemorrhage protocol and one rat survived for the whole 6 hours postbleeding observation period.
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Animal Model:HD150KI mice[2]
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Dosage:1 mg/kg
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Administration:Intraperitoneally injected; three times a week up to 57 weeks
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Result:Chronic treatment suppressed weight loss. Increased the average body mass by 22%.
Chemical Information
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CAS No. 866404-31-1
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Appearance Solid
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Molecular Weight 960.25
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Formula C53H81N7O9
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Color Off-white to pink
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SMILES
CC(C)(C)OC(N[C@@H](CC(C)C)/C=C/[C@H](CC1=CC=CC=C1)C(N2[C@@H](CCC2)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(OCC3=CC=CC=C3)=O)C(NC4CC(C)(N(O)C(C)(C4)C)C)=O)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (6)
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Journal Impact Factor
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Most Recent
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Bone Res
Isovitexin targets SIRT3 to prevent steroid-induced osteonecrosis of the femoral head by modulating mitophagy-mediated ferroptosis. [Abstract]2025 Jan 26;13(1):18. PMID: 39865068 -
Sci Immunol
PTMA safeguards mitochondrial integrity to sustain metabolic function and antitumor activity of CD8 T cells. [Abstract]2026 Jan 23;11(115):eadz7275. PMID: 41544148 -
Cell Prolif
KLF2/PPARγ axis contributes to trauma-induced heterotopic ossification by regulating mitochondrial dysfunction. [Abstract]2024 Jan;57(1):e13521. PMID: 37340819 -
Mol Neurobiol
2025 Mar;62(3):3125-3142. PMID: 39230869 -
J Inorg Biochem
Novel erbium complex with anticancer activity against radiation resistant lung adenocarcinoma cells. [Abstract]2025 Aug:269:112902. PMID: 40132280 -
Discov Oncol
HSF1 is a novel prognostic biomarker in high-risk prostate cancer that correlates with ferroptosis. [Abstract]2023 Jun 23;14(1):107. PMID: 37351671
Solvent & Solubility
DMSO : 125 mg/mL (130.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (2.17 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Carlos A Macias, et al. Treatment with a novel hemigramicidin-TEMPO conjugate prolongs survival in a rat model of lethal hemorrhagic shock. Ann Surg. 2007 Feb;245(2):305-14. [Content Brief]
[2]. Zhiyin Xun, et al. Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease. Cell Rep. 2012 Nov 29;2(5):1137-42. [Content Brief]
[3]. Julie P Goff, et al. Evaluation of potential ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cells. Exp Hematol. 2013 Nov;41(11):957-66. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0414 mL | 5.2070 mL | 10.4140 mL | 26.0349 mL |
| 5 mM | 0.2083 mL | 1.0414 mL | 2.0828 mL | 5.2070 mL | |
| 10 mM | 0.1041 mL | 0.5207 mL | 1.0414 mL | 2.6035 mL | |
| 15 mM | 0.0694 mL | 0.3471 mL | 0.6943 mL | 1.7357 mL | |
| 20 mM | 0.0521 mL | 0.2603 mL | 0.5207 mL | 1.3017 mL | |
| 25 mM | 0.0417 mL | 0.2083 mL | 0.4166 mL | 1.0414 mL | |
| 30 mM | 0.0347 mL | 0.1736 mL | 0.3471 mL | 0.8678 mL | |
| 40 mM | 0.0260 mL | 0.1302 mL | 0.2603 mL | 0.6509 mL | |
| 50 mM | 0.0208 mL | 0.1041 mL | 0.2083 mL | 0.5207 mL | |
| 60 mM | 0.0174 mL | 0.0868 mL | 0.1736 mL | 0.4339 mL | |
| 80 mM | 0.0130 mL | 0.0651 mL | 0.1302 mL | 0.3254 mL | |
| 100 mM | 0.0104 mL | 0.0521 mL | 0.1041 mL | 0.2603 mL |
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