Novel erbium complex with anticancer activity against radiation resistant lung adenocarcinoma cells

  • J Inorg Biochem. 2025 Mar 19:269:112902. doi: 10.1016/j.jinorgbio.2025.112902.
Hao Wang  1 ,  Guozhu Ren  2 ,  Yue Xu  2 ,  Ruiping Deng  2 ,  Rui Wang  3 ,  Liang Zhou  4
Affiliations
  • 1. School of Materials Science and Engineering, Jilin Jianzhu University, Changchun 130118, China.
  • 2. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
  • 3. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. Electronic address: [email protected].
  • 4. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. Electronic address: [email protected].
PMID: 40132280 DOI: 10.1016/j.jinorgbio.2025.112902
Abstract

In this work, novel erbium complex with Anticancer activity against radiation resistant lung adenocarcinoma cells was obtained and demonstrated. Firstly, stronger inhibitory effect of Er3+ on non-small cell lung Cancer (NSCLC) cells and NSCLC- radiation resistant (RR) cells was experimentally confirmed. Then, by selecting highly biocompatible porphyrins as ligands, a novel erbium complex tetraphenylporphyrin erbium acetylacetonate (Er(acac)TPP) was synthesized and purified. Compared with Cisplatin, notably, Er(acac)TPP exhibits relatively higher inhibitory efficiency on NSCLC-RR cells. Moreover, the toxicities of Er(acac)TPP to normal cells are much lower than that of Cancer cells. Subsequently, cell expansion, increased Apoptosis, a decline in mitochondrial membrane potential (MMP), an accumulation of intracellular Reactive Oxygen Species (ROS), increased Caspase-9 protein level and G2/M arrest were seen. These data all pointed to Er(acac)TPP as a possible candidate for more research and development as a chemotherapeutic drug.

Keywords
Anticancer activity; Chemotherapy drugs; Erbium complex; Non-small cell lung cancer; Radiation resistant cells.
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