1. GPCR/G Protein
    Apoptosis
  2. Glucocorticoid Receptor
    Apoptosis
  3. Betamethasone

Betamethasone 

Cat. No.: HY-13570 Purity: 99.97%
Handling Instructions

Betamethasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone accelerates fetal lung maturation and induces gene expression and apoptosis.

For research use only. We do not sell to patients.

Betamethasone Chemical Structure

Betamethasone Chemical Structure

CAS No. : 378-44-9

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10 mM * 1 mL in DMSO USD 66 In-stock
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Description

Betamethasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone accelerates fetal lung maturation and induces gene expression and apoptosis[1][2][3][4].

In Vitro

Betamethasone (0.1-1 μM; 12 h) induces gene expression in L929 cells[4].
Betamethasone (0.1-1 μM; 48 h) induces CEM C7 T-cells apoptosis[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Betamethasone (0.48 mg; i.v.gtt for 48 h) decreases the hypercapnia-induced increase in CBF due to decreased cerebral vasodilatation[1]. Betamethasone (0.05 ml (1 mg/L); topical injection) ameliorates spinal nerve transection induced mechanical allodynia and thermal hyperalgesia, and reduces the activation of NF-κB and elevation of TNFα and IL-1β, and induces the expression of IL-10 in the rats brain[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rambouillet-Colombia ewes bred on a single occasion are received hypercapnic challenges[1]
Dosage: 0.48 mg
Administration: Injected into the fetal jugular vein at a rate of 1 ml/h (10 μg betamethasone/h) and maintained over the next 48 h.
Result: Decreased cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 h of infusion.
The reduction in CBF was diminished to about 25-30 % after 48 h of infusion.
Clinical Trial
Molecular Weight

392.46

Formula

C₂₂H₂₉FO₅

CAS No.
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Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (127.40 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5480 mL 12.7402 mL 25.4803 mL
5 mM 0.5096 mL 2.5480 mL 5.0961 mL
10 mM 0.2548 mL 1.2740 mL 2.5480 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.37 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.37 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.37 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BetamethasoneGlucocorticoid ReceptorApoptosisglucocorticoidanti-inflammatoryimmunosuppressivefetallungmaturationgeneexpressionapoptosisInhibitorinhibitorinhibit

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Betamethasone
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HY-13570
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