Betamethasone hydrochloride
Based on 3 publication(s) in Google Scholar
Betamethasone hydrochloride is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone hydrochloride accelerates fetal lung maturation and induces gene expression and apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 956901-32-9
- Formula: C22H30ClFO5
- Molecular Weight:428.92
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Biological Activity
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Animal Model:Rambouillet-Colombia ewes bred on a single occasion are received hypercapnic challenges[1]
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Dosage:0.48 mg
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Administration:Injected into the fetal jugular vein at a rate of 1 ml/h (10 μg betamethasone/h) and maintained over the next 48 h.
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Result:Decreased cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 h of infusion.
The reduction in CBF was diminished to about 25-30 % after 48 h of infusion.
Chemical Information
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CAS No. 956901-32-9
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Molecular Weight 428.92
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Formula C22H30ClFO5
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SMILES
C[C@@]12[C@](C[C@H](C)[C@]2(O)C(CO)=O)([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C1)=O.Cl
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Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Cell Metab
Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury. [Abstract]2024 Nov 5;36(11):2402-2418.e10. PMID: 39389061 -
Cell Death Differ
Functional genomic screens uncover FERMT2 as a critical regulator of YAP/TAZ-driven tumorigenicity. [Abstract]2026 Mar 6. PMID: 41792242
Betamethasone hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2026 Mar 6. [Abstract]
Western Blotting analysis of MDA-MB-231-Cas9 treated with Betamethasone (B-Met, 1 μM; 24 h). GAPDH was used as the loading control.
Betamethasone hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2026 Mar 6. [Abstract]
Betamethasone (B-Met, 1 μM; 24 h). RT-qPCR analysis of a glucocorticoid responsive gene, GILZ1.
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Proc Natl Acad Sci U S A
2022 Apr 12;119(15):e2117004119. PMID: 35394864
Purity & Documentation
References
[1]. Schwab M, et, al. Effects of betamethasone administration to the fetal sheep in late gestation on fetal cerebral blood flow. J Physiol. 2000 Nov 1;528(Pt 3):619-32. [Content Brief]
[2]. Xie W, et, al. Betamethasone affects cerebral expressions of NF-kappaB and cytokines that correlate with pain behavior in a rat model of neuropathy. Ann Clin Lab Sci. Winter 2006;36(1):39-46. [Content Brief]
[3]. Kubin ME, et, al. Clinical Efficiency of Topical Calcipotriol/Betamethasone Treatment in Psoriasis Relies on Suppression of the Inflammatory TNFα - IL-23 - IL-17 Axis. Acta Derm Venereol. 2017 Apr 6;97(4):449-455. [Content Brief]
[4]. Hofmann TH, et, al. Various glucocorticoids differ in their ability to induce gene expression, apoptosis and to repress NF-kappaB-dependent transcription. FEBS Lett. 1998 Dec 28;441(3):441-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Betamethasone hydrochloride Related Classifications
HY-13570A Related Classifications
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