1. GPCR/G Protein
    Apoptosis
  2. Glucocorticoid Receptor
    Apoptosis
  3. Betamethasone hydrochloride

Betamethasone hydrochloride 

Cat. No.: HY-13570A
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Betamethasone hydrochloride is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone hydrochloride accelerates fetal lung maturation and induces gene expression and apoptosis.

For research use only. We do not sell to patients.

Betamethasone hydrochloride Chemical Structure

Betamethasone hydrochloride Chemical Structure

CAS No. : 956901-32-9

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Description

Betamethasone hydrochloride is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone hydrochloride accelerates fetal lung maturation and induces gene expression and apoptosis[1][2][3][4].

In Vitro

Betamethasone (0.1-1 μM; 12 h) induces gene expression in L929 cells[4].
Betamethasone (0.1-1 μM; 48 h) induces CEM C7 T-cells apoptosis[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Betamethasone (0.48 mg; i.v.gtt for 48 h) decreases the hypercapnia-induced increase in CBF due to decreased cerebral vasodilatation[1]. Betamethasone (0.05 ml (1 mg/L); topical injection) ameliorates spinal nerve transection induced mechanical allodynia and thermal hyperalgesia, and reduces the activation of NF-κB and elevation of TNFα and IL-1β, and induces the expression of IL-10 in the rats brain[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rambouillet-Colombia ewes bred on a single occasion are received hypercapnic challenges[1]
Dosage: 0.48 mg
Administration: Injected into the fetal jugular vein at a rate of 1 ml/h (10 μg betamethasone/h) and maintained over the next 48 h.
Result: Decreased cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 h of infusion.
The reduction in CBF was diminished to about 25-30 % after 48 h of infusion.
Clinical Trial
Molecular Weight

428.92

Formula

C₂₂H₃₀ClFO₅

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BetamethasoneGlucocorticoid ReceptorApoptosisglucocorticoidanti-inflammatoryimmunosuppressivefetallungmaturationgeneexpressionapoptosisInhibitorinhibitorinhibit

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Betamethasone hydrochloride
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HY-13570A
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