1. GPCR/G Protein
  2. Glucocorticoid Receptor
  3. Beclometasone

Beclometasone (Synonyms: Beclomethasone)

Cat. No.: HY-B1540 Purity: 95.44%
Handling Instructions

Beclometasone (Beclomethasone) is a prototype glucocorticoid receptor agonist.

For research use only. We do not sell to patients.

Beclometasone Chemical Structure

Beclometasone Chemical Structure

CAS No. : 4419-39-0

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10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
25 mg USD 84 In-stock
Estimated Time of Arrival: December 31
50 mg USD 132 In-stock
Estimated Time of Arrival: December 31
100 mg USD 180 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Beclometasone (Beclomethasone) is a prototype glucocorticoid receptor agonist.

IC50 & Target

Glucocorticoid Receptor[1]

In Vitro

An inhibition of the normal physiological neutrophil migration and of neutrophil chemotaxis directed by wounding-induced inflammation is detected at 4 h after administration of 25 μM Beclomethasone. Tumour cell invasion and micrometastasis is also reduced in embryos incubated in 25 μM Beclomethasone 4 h before implantation. In addition, the lysyl oxidase inhibitor β-aminoproprionitrile (βAPN) largely reduces fibrillar collagen and enhances the CHT-TF transmigration of neutrophils, leading to a significant increase of tumour cell invasion and subsequent formation of micrometastases. Notably, βAPN inhibits neutrophil chemotaxis induced by inflammation, indicating that the increase of tumour cell invasion in βAPN-treated embryos is correlated with enhanced non-pathological neutrophil migration, but not with inflammation[1].

Clinical Trial
Molecular Weight

408.92

Formula

C₂₂H₂₉ClO₅

CAS No.

4419-39-0

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (78.25 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4455 mL 12.2273 mL 24.4547 mL
5 mM 0.4891 mL 2.4455 mL 4.8909 mL
10 mM 0.2445 mL 1.2227 mL 2.4455 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

The transgenic lines Tg(fli1:GFP) and Tg(mpx:GFP) are used in this study. 0.2 mM N-phenylthiourea (PTU) is applied to prevent pigment formation from 1 day post-fertilization (dpf). For Pu.1 knockdown, Pu.1 MO (1 mM for partial knockdown and 2 mM for complete knockdown is injected into the yolk at the one-cell stage. For pharmacological inhibition, the VEGFR tyrosine kinase inhibitors KRN633 (0.1-1 μM) or Sunitinib (0.1-1 μM), Beclomethasone (25 μM) and β-amino-proprionitrile (βAPN, 500 μM) are applied directly to the egg water and refreshed every 2 days. For pharmacological inhibition, Beclomethasone is applied to the embryos 4 h before implantation and KRN633, Sunitinib and βAPN are applied 4-6 h post-implantation. For each cell line or condition, data are representative of ≥ three independent experiments, with ≥30 embryos/group. Experiments are discarded when the survival rate of the control group is <90%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Beclometasone
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