Beclometasone dipropionate
Based on 4 publication(s) in Google Scholar
Beclometasone dipropionate, the proagent of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate can be used for asthma .
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.80%
- CAS No.: 5534-09-8
- 화학식: C28H37ClO7
- 분자량:521.04
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
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FlumethasoneGR Agonist -
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Betamethasone valerateGlucocorticoid -
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Beclometasone dipropionate (Standard)Glucocorticoid Receptor Agonist -
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PrednisoloneGlucocorticoid -
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CorticosteroneEndogenous Glucocorticoids
Publications Citing Use of MedChemExpress (MCE) Beclometasone dipropionate
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Biological Activity
제품 설명
IC50 & Target
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iNOS |
In Vitro
Beclometasone dipropionate (1-100 nM; 20 min) inhibits STAT-1 expression and reduces the levels of iNOS, ROS and NT generated by rhIL-17A in 16HBE cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:16HBE cells
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Concentration:1, 10 and 100 nM
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Incubation Time:20 min
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Result:Reduced the levels of iNOS, ROS and NT generated by rhIL-17A.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ten-week-old male Balb/c mice[2].
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Dosage:5 mg/kg (100 μg/ml for 60 min).
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Administration:Orally at 24 h and 1 h before the LPS aerosol.
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Result:Significantly (P < 0.05) inhibited the decrease of IL-10 level in BAL fluid induced by LPS exposure.
Markedly reduced the release of both MMP-2 and MMP-9.
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Animal Model:Male BALB/c mice with asthma[1]
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Dosage:150 µg/kg
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Administration:Nebulization
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Result:Decreased total cell number and relative eosinophil number in BALF.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 5534-09-8
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Appearance Solid
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분자량 521.04
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화학식 C28H37ClO7
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Color White to off-white
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SMILES
C[C@@]12[C@](C[C@H](C)[C@]2(OC(CC)=O)C(COC(CC)=O)=O)([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C1)=O
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Synonyms
Beclomethasone dipropionate
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (4)
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Journal Impact Factor
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Most Recent
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Drug Deliv Transl Res
Leveraging quantum chemical properties in transfer learning for predicting blood-brain barrier permeability of drugs. [Abstract]2025 Oct 29. PMID: 41160380 -
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Sci Total Environ
Development and validation of an activated immune model with zebrafish eleutheroembryo based on caudal fin acupuncture. [Abstract]2021 Sep 1:785:147288. PMID: 33930807 -
용액&용해도
In Vitro:
DMSO : ≥ 100 mg/mL (191.92 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.80 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (282 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. Hrvacić B, et, al. Applicability of an ultrasonic nebulization system for the airways delivery of beclomethasone dipropionate in a murine model of asthma. Pharm Res. 2006 Aug;23(8):1765-75. [Content Brief]
[2]. Montalbano AM, et, al. Beclomethasone dipropionate and formoterol reduce oxidative/nitrosative stress generated by cigarette smoke extracts and IL-17A in human bronchial epithelial cells. Eur J Pharmacol. 2013 Oct 15;718(1-3):418-27. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9192 mL | 9.5962 mL | 19.1924 mL | 47.9810 mL |
| 5 mM | 0.3838 mL | 1.9192 mL | 3.8385 mL | 9.5962 mL | |
| 10 mM | 0.1919 mL | 0.9596 mL | 1.9192 mL | 4.7981 mL | |
| 15 mM | 0.1279 mL | 0.6397 mL | 1.2795 mL | 3.1987 mL | |
| 20 mM | 0.0960 mL | 0.4798 mL | 0.9596 mL | 2.3990 mL | |
| 25 mM | 0.0768 mL | 0.3838 mL | 0.7677 mL | 1.9192 mL | |
| 30 mM | 0.0640 mL | 0.3199 mL | 0.6397 mL | 1.5994 mL | |
| 40 mM | 0.0480 mL | 0.2399 mL | 0.4798 mL | 1.1995 mL | |
| 50 mM | 0.0384 mL | 0.1919 mL | 0.3838 mL | 0.9596 mL | |
| 60 mM | 0.0320 mL | 0.1599 mL | 0.3199 mL | 0.7997 mL | |
| 80 mM | 0.0240 mL | 0.1200 mL | 0.2399 mL | 0.5998 mL | |
| 100 mM | 0.0192 mL | 0.0960 mL | 0.1919 mL | 0.4798 mL |
Beclometasone dipropionate Related Classifications
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