2. Immunology/Inflammation
    Vitamin D Related/Nuclear Receptor
    NF-κB
    Metabolic Enzyme/Protease
  3. Glucocorticoid Receptor
    Reactive Oxygen Species
    NO Synthase
  4. Beclometasone dipropionate

Beclometasone dipropionate  (Synonyms: Beclomethasone dipropionate )

Cat. No.: HY-13571A Purity: 99.89%
COA Handling Instructions

Beclometasone dipropionate, the prodrug of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate can be used for asthma .

For research use only. We do not sell to patients.

Beclometasone dipropionate Chemical Structure

Beclometasone dipropionate Chemical Structure

CAS No. : 5534-09-8

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Based on 3 publication(s) in Google Scholar

Other Forms of Beclometasone dipropionate:

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Description

Beclometasone dipropionate, the prodrug of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate can be used for asthma [1][2].

IC50 & Target

iNOS

 

In Vitro

Beclometasone dipropionate (1-100 nM; 20 min) inhibits STAT-1 expression and reduces the levels of iNOS, ROS and NT generated by rhIL-17A in 16HBE cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: 16HBE cells
Concentration: 1, 10 and 100 nM
Incubation Time: 20 min
Result: Reduced the levels of iNOS, ROS and NT generated by rhIL-17A.
In Vivo

Beclometasone dipropionate (150 µg/kg; nebulization; male BALB/c mice) relieves asthma and decreases total cell number and relative eosinophil number[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ten-week-old male Balb/c mice[2].
Dosage: 5 mg/kg (100 μg/ml for 60 min).
Administration: Orally at 24 h and 1 h before the LPS aerosol.
Result: Significantly (P < 0.05) inhibited the decrease of IL-10 level in BAL fluid induced by LPS exposure.
Markedly reduced the release of both MMP-2 and MMP-9.
Animal Model: Male BALB/c mice with asthma[1]
Dosage: 150 µg/kg
Administration: Nebulization
Result: Decreased total cell number and relative eosinophil number in BALF.
Clinical Trial
Molecular Weight

521.04

Appearance

Solid

Formula

C28H37ClO7
CAS No.
SMILES
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (191.92 mM)

H2O : < 0.1 mg/mL (ultrasonic) (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9192 mL 9.5962 mL 19.1924 mL
5 mM 0.3838 mL 1.9192 mL 3.8385 mL
10 mM 0.1919 mL 0.9596 mL 1.9192 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.80 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.80 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.89%

COA (254 KB) HNMR (226 KB) LCMS (449 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Beclometasone5534-09-8Beclomethasone dipropionate Glucocorticoid ReceptorReactive Oxygen SpeciesNO SynthaseNitric oxide synthasesNOSSTAT-1iNOS16HBE cellsasthmainflammationInhibitorinhibitorinhibit

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