1. GPCR/G Protein
  2. Glucocorticoid Receptor
  3. Beclometasone dipropionate

Beclometasone dipropionate 

Cat. No.: HY-13571A Purity: 99.92%
Handling Instructions

Betamethasone dipropionate, the prodrug of Betamethasone, is an orally active and potent glucocorticoid with anti-inflammatory and immunosuppressive activity. Betamethasone appears to be an effective inhibitor of LPS-induced inflammation and MMP release.

For research use only. We do not sell to patients.

Beclometasone dipropionate Chemical Structure

Beclometasone dipropionate Chemical Structure

CAS No. : 5534-09-8

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10 mM * 1 mL in DMSO USD 66 In-stock
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250 mg USD 60 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Beclometasone dipropionate:

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Description

Betamethasone dipropionate, the prodrug of Betamethasone, is an orally active and potent glucocorticoid with anti-inflammatory and immunosuppressive activity. Betamethasone appears to be an effective inhibitor of LPS-induced inflammation and MMP release[1][2].

In Vitro

The Calcipotriol/Betamethasone combination significantly inhibits the secretion of IL-17A and TNF-α in psoriatic skin. Additionally, the two components show additive inhibitory effects on secretion of IL-23 and TNF-α by DCs, of IL-17A and TNF-α by both CD4+ and CD8+ T cells and reduced inflammatory responses in Th17-stimulated keratinocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: Pig and human skin.
Concentration: 1 μM.
Incubation Time: 24 h.
Result: Additively inhibit expression of inflammatory cytokines in psoriasis skin explant cultures.
Affected the activity of DCs resulting in a decreased secretion of TNF-α and IL-23.
In Vivo

Betamethasone (5 mg/kg, orally) reduces the LPS-induced pulmonary inflammation and production of MMPs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ten-week-old male Balb/c mice[2].
Dosage: 5 mg/kg (100 μg/ml for 60 min).
Administration: Orally at 24 h and 1 h before the LPS aerosol.
Result: Significantly (P < 0.05) inhibited the decrease of IL-10 level in BAL fluid induced by LPS exposure.
Markedly reduced the release of both MMP-2 and MMP-9.
Clinical Trial
Molecular Weight

521.04

Formula

C₂₈H₃₇ClO₇

CAS No.

5534-09-8

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (191.92 mM)

H2O : 1 mg/mL (1.92 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9192 mL 9.5962 mL 19.1924 mL
5 mM 0.3838 mL 1.9192 mL 3.8385 mL
10 mM 0.1919 mL 0.9596 mL 1.9192 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.80 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.80 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.92%

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Keywords:

BeclometasoneGlucocorticoid ReceptorMMPLPSTNF-αIL-23IL-17ApsoriasisarthritisInhibitorinhibitorinhibit

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Product Name:
Beclometasone dipropionate
Cat. No.:
HY-13571A
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