1. GPCR/G Protein
    Metabolic Enzyme/Protease
  2. Glucocorticoid Receptor
    Endogenous Metabolite
  3. Cortisone

Cortisone (Synonyms: 17-Hydroxy-11-dehydrocorticosterone; Kendall's compound E)

Cat. No.: HY-17461 Purity: 99.90%
Handling Instructions

Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.

For research use only. We do not sell to patients.

Cortisone Chemical Structure

Cortisone Chemical Structure

CAS No. : 53-06-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
100 mg USD 72 In-stock
Estimated Time of Arrival: December 31
500 mg USD 120 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Cortisone (2.8-28,000 nM) dose-dependently attenuates the apoptosis induced by Cortisol in peripheral-blood mononuclear cells (PBMCs)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cortisone (2 mg/kg; i.m. on alternate days for 2 months) decreases the BCG (the vaccine strain of tubercle bacillus) lesions and tuberculin reactions in rabbits[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male New Zealand white rabbits (2.1-2.4 kg) were injected with BCG at six days after the first administrtion[2]
Dosage: 2 mg/kg
Administration: Intramuscular injection on alternate days for 2 months
Result: Reduced the BCG lesions and tuberculin reactions.
Reduced the number of infiltrating mononuclear cells (MN), the amount of caseous necrosis and ulceration, and the percent of NM that were beta-galactosidase-positive.
Clinical Trial
Molecular Weight

360.44

Formula

C₂₁H₂₈O₅

CAS No.

53-06-5

SMILES

C[[email protected]@]1(C2)[[email protected]](C(CO)=O)(O)CC[[email protected]@]1([H])[[email protected]]3([H])CCC4=CC(CC[[email protected]]4(C)[[email protected]@]3([H])C2=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (277.44 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7744 mL 13.8719 mL 27.7439 mL
5 mM 0.5549 mL 2.7744 mL 5.5488 mL
10 mM 0.2774 mL 1.3872 mL 2.7744 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.90%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Cortisone17-Hydroxy-11-dehydrocorticosterone Kendall's compound EGlucocorticoid ReceptorEndogenous Metaboliteimmunosuppressantanti-inflammatoryInhibitorinhibitorinhibit

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Cortisone
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HY-17461
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