2. Immunology/Inflammation
    Vitamin D Related/Nuclear Receptor
    Metabolic Enzyme/Protease
  3. Glucocorticoid Receptor
    Endogenous Metabolite
  4. Cortisone acetate

Cortisone acetate  (Synonyms: Cortisone 21-acetate)

Cat. No.: HY-17461A Purity: 99.63%
COA Handling Instructions

Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.

For research use only. We do not sell to patients.

Cortisone acetate Chemical Structure

Cortisone acetate Chemical Structure

CAS No. : 50-04-4

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Based on 1 publication(s) in Google Scholar

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Description

Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].

IC50 & Target

Glucocorticoid-receptor[1]
In Vitro

Cortisone (2.8-28,000 nM) dose-dependently attenuates the apoptosis induced by Cortisol in peripheral-blood mononuclear cells (PBMCs)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Cortisone (2 mg/kg; i.m. on alternate days for 2 months) decreases the BCG (the vaccine strain of tubercle bacillus) lesions and tuberculin reactions in rabbits[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male New Zealand white rabbits (2.1-2.4 kg) were injected with BCG at six days after the first administrtion[2]
Dosage: 2 mg/kg
Administration: Intramuscular injection on alternate days for 2 months
Result: Reduced the BCG lesions and tuberculin reactions.
Reduced the number of infiltrating mononuclear cells (MN), the amount of caseous necrosis and ulceration, and the percent of NM that were beta-galactosidase-positive.
Clinical Trial
Molecular Weight

402.48

Appearance

Solid

Formula

C23H30O6
CAS No.
SMILES

C[[email protected]@]1(C2)[[email protected]](C(COC(C)=O)=O)(O)CC[[email protected]@]1([H])[[email protected]]3([H])CCC4=CC(CC[[email protected]]4(C)[[email protected]@]3([H])C2=O)=O
Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 6.8 mg/mL (16.90 mM; Need ultrasonic and warming)

H2O : 1 mg/mL (2.48 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4846 mL 12.4230 mL 24.8460 mL
5 mM 0.4969 mL 2.4846 mL 4.9692 mL
10 mM 0.2485 mL 1.2423 mL 2.4846 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.5 mg/mL (1.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.5 mg/mL (1.24 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.5 mg/mL (1.24 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.63%

COA (252 KB) LCMS (264 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Cortisone50-04-4Cortisone 21-acetateGlucocorticoid ReceptorEndogenous Metaboliteimmunosuppressantanti-inflammatoryInhibitorinhibitorinhibit

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