1. GPCR/G Protein
  2. Glucocorticoid Receptor
  3. Betamethasone valerate

Betamethasone valerate (Synonyms: Betamethasone 17-valerate)

Cat. No.: HY-B0727
Handling Instructions

Betamethasone valerate (Betamethasone 17-valerate), the 17-valerate ester of Betamethasone, is a topical corticosteroid with anti-inflammatory activity. Betamethasone valerate is used in the treatment of recurrent aphthous stomatitis. Betamethasone valerate inhibits the binding of the radiolabeled glucocorticoid dexamethasone (3H dexamethasone) to human epidermis and mouse skin with IC50s of 5 and 6 nM, respectively.

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Betamethasone valerate Chemical Structure

Betamethasone valerate Chemical Structure

CAS No. : 2152-44-5

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Description

Betamethasone valerate (Betamethasone 17-valerate), the 17-valerate ester of Betamethasone, is a topical corticosteroid with anti-inflammatory activity. Betamethasone valerate is used in the treatment of recurrent aphthous stomatitis. Betamethasone valerate inhibits the binding of the radiolabeled glucocorticoid dexamethasone (3H dexamethasone) to human epidermis and mouse skin with IC50s of 5 and 6 nM, respectively[1][2][3].

In Vivo

Betamethasone valerate (10 mg; 5 minutes; applied to the irritated site with a micro spatula) ointment inhibits about 50% of the ear edema without thymus atrophy[4].
Betamethasone-17-valerate ointment (50 mg) inhibits homologous passive cutaneous anaphylaxis[4].

Animal Model: Female Sprague-Dawley rats weighing 60-70 g (croton oil edema experiment)[4]
Dosage: 10 mg
Administration: Applied to the irritated site with a micro spatula; 5 minutes
Result: Inhibited about 50% of the ear edema without thymus atrophy.
Clinical Trial
Molecular Weight

476.58

Formula

C₂₇H₃₇FO₆

CAS No.

2152-44-5

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Betamethasone valerateBetamethasone 17-valerateGlucocorticoid ReceptorglucocorticoidantiinflammatorytopicaluserecurrentaphthousstomatitisInhibitorinhibitorinhibit

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