1. GPCR/G Protein
  2. Glucocorticoid Receptor
  3. Betamethasone valerate

Betamethasone valerate (Synonyms: Betamethasone 17-valerate)

Cat. No.: HY-B0727 Purity: 99.14%
Handling Instructions

Betamethasone valerate (Betamethasone 17-valerate), the 17-valerate ester of Betamethasone, is a topical corticosteroid with anti-inflammatory activity. Betamethasone valerate is used in the treatment of recurrent aphthous stomatitis. Betamethasone valerate inhibits the binding of the radiolabeled glucocorticoid dexamethasone (3H dexamethasone) to human epidermis and mouse skin with IC50s of 5 and 6 nM, respectively.

For research use only. We do not sell to patients.

Betamethasone valerate Chemical Structure

Betamethasone valerate Chemical Structure

CAS No. : 2152-44-5

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Based on 1 publication(s) in Google Scholar

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Description

Betamethasone valerate (Betamethasone 17-valerate), the 17-valerate ester of Betamethasone, is a topical corticosteroid with anti-inflammatory activity. Betamethasone valerate is used in the treatment of recurrent aphthous stomatitis. Betamethasone valerate inhibits the binding of the radiolabeled glucocorticoid dexamethasone (3H dexamethasone) to human epidermis and mouse skin with IC50s of 5 and 6 nM, respectively[1][2][3].

In Vivo

Betamethasone valerate (10 mg; 5 minutes; applied to the irritated site with a micro spatula) ointment inhibits about 50% of the ear edema without thymus atrophy[4].
Betamethasone-17-valerate ointment (50 mg) inhibits homologous passive cutaneous anaphylaxis[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Sprague-Dawley rats weighing 60-70 g (croton oil edema experiment)[4]
Dosage: 10 mg
Administration: Applied to the irritated site with a micro spatula; 5 minutes
Result: Inhibited about 50% of the ear edema without thymus atrophy.
Clinical Trial
Molecular Weight

476.58

Formula

C₂₇H₃₇FO₆

CAS No.
SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (209.83 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0983 mL 10.4914 mL 20.9828 mL
5 mM 0.4197 mL 2.0983 mL 4.1966 mL
10 mM 0.2098 mL 1.0491 mL 2.0983 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.25 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.25 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.25 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Betamethasone valerateBetamethasone 17-valerateGlucocorticoid ReceptorglucocorticoidantiinflammatorytopicaluserecurrentaphthousstomatitisInhibitorinhibitorinhibit

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Betamethasone valerate
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