2152-44-5
Chemical Structure
Betamethasone valerate
Synonym(s): Betamethasone 17-valerate
- CAS No.: 2152-44-5
- Formula:C27H37FO6
- Molecular Weight:476.58
IUPAC Name: (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl pentanoate
InChIKey: SNHRLVCMMWUAJD-SUYDQAKGSA-N
SMILES: C[C@@]12[C@](C(CO)=O)(OC(CCCC)=O)[C@@H](C)C[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C2)=O
Biological Activity: Betamethasone valerate (Betamethasone 17-valerate), the 17-valerate ester of Betamethasone, is a topical corticosteroid with anti-inflammatory activity. Betamethasone valerate is used in the treatment of recurrent aphthous stomatitis. Betamethasone valerate inhibits the binding of the radiolabeled glucocorticoid dexamethasone (3H dexamethasone) to human epidermis and mouse skin with IC50s of 5 and 6 nM, respectively[1][2][3].
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Betamethasone valerate | 99.81% | Betamethasone valerate (Betamethasone 17-valerate), the 17-valerate ester of Betamethasone, is a topical corticosteroid with anti-inflammatory activity. Betamethasone valerate is used in the treatment of recurrent aphthous stomatitis. Betamethasone valerate inhibits the binding of the radiolabeled glucocorticoid dexamethasone (3H dexamethasone) to human epidermis and mouse skin with IC50s of 5 and 6 nM, respectively. | ||||||||||||||||||||
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Betamethasone valerate (Standard) | ≥98% | Betamethasone valerate (Standard) is the analytical standard of Betamethasone valerate. This product is intended for research and analytical applications. Betamethasone valerate (Betamethasone 17-valerate), the 17-valerate ester of Betamethasone, is a topical corticosteroid with anti-inflammatory activity. Betamethasone valerate is used in the treatment of recurrent aphthous stomatitis. Betamethasone valerate inhibits the binding of the radiolabeled glucocorticoid dexamethasone (3H dexamethasone) to human epidermis and mouse skin with IC50s of 5 and 6 nM, respectively. | ||||||||||||||||||||
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Similarity Score 1.00
HY-Z8849Betamethasone valerate impurity 3 -
Similarity Score 0.92
HY-W342458Betamethasone 17-Propionate -
Similarity Score 0.85
HY-B0775Betamethasone-17-butyrate-21-propionate -
Similarity Score 0.84
HY-13600Clobetasol propionate -
Similarity Score 0.84
HY-139352RBetamethasone 21-valerate (Standard) -
Similarity Score 0.83
HY-148661Betamethasone acetate impurity 3 -
Similarity Score 0.83
HY-13571Betamethasone dipropionate -
Similarity Score 0.83
HY-W740983Dexamethasone dipropionate -
Similarity Score 0.81
HY-Z8852Betamethasone valerate impurity 1 -
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References
- [1]. Sizílio RH, et al. Chitosan/pvp-based mucoadhesive membranes as a promising delivery system of betamethasone-17-valerate for aphthous stomatitis. Carbohydr Polym. 2018 Jun 15;190:339-345. [Content Brief]
- [2]. Epstein EH Jr, et al. Glucocorticoid receptors of normal human epidermis. J Invest Dermatol. 1982 Feb;78(2):144-6. [Content Brief]
- [3]. WILLIAMS DI, et al. BETAMETHASONE 17-VALERATE: A NEW TOPICAL CORTICOSTEROID. Lancet. 1964 May 30;1(7344):1177-9. [Content Brief]
