Betamethasone 17-Propionate

Cat. No.: HY-W342458 Purity: 98.83%: Data Sheet
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Betamethasone 17-Propionate is a compound used to study its effects on endotoxin-induced uveitis in rats. It has the activity of inhibiting the infiltration of cells into the aqueous humor in endotoxin-induced uveitis by eye drops and systemic administration at a certain dose. However, its inhibitory effect is relatively weak compared with some other compounds. At the same time, the dose for systemic administration is 1mg/kg. In addition, Betamethasone 17-Propionate has a weaker inhibitory effect on the release of IL-8 from rat peritoneal exudate cells in an in vitro interleukin-8 (IL-8) release assay than betamethasone. Moreover, the simultaneous addition of betamethasone dipropionate and betamethasone 17-Propionate reduces the inhibitory effect of betamethasone on cell infiltration and IL-1β gene expression.

For research use only. We do not sell to patients.

Betamethasone 17-Propionate Chemical Structure

CAS No. : 5534-13-4

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Betamethasone 17-Propionate:

Betamethasone 17-propionate-d₅ Get quote
Betamethasone 17-propionate-d₄ Get quote

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

448.52

Formula

C₂₅H₃₃FO₆

CAS No.

5534-13-4

Appearance

Solid

Color

White to off-white

SMILES

CCC(O[C@]1([C@@]2([C@@]([C@@]3([H])[C@]([C@H](C2)O)([C@@]4(C(CC3)=CC(C=C4)=O)C)F)([H])C[C@@H]1C)C)C(CO)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (222.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2296 mL	11.1478 mL	22.2956 mL
5 mM	0.4459 mL	2.2296 mL	4.4591 mL
10 mM	0.2230 mL	1.1148 mL	2.2296 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.83%

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Data Sheet (274 KB) SDS (419 KB)

COA (255 KB) HNMR (138 KB) RP-HPLC (229 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. The effects of betamethasone derivatives on endotoxin-induced uveitis in rats

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2296 mL	11.1478 mL	22.2956 mL	55.7389 mL
	5 mM	0.4459 mL	2.2296 mL	4.4591 mL	11.1478 mL
	10 mM	0.2230 mL	1.1148 mL	2.2296 mL	5.5739 mL
	15 mM	0.1486 mL	0.7432 mL	1.4864 mL	3.7159 mL
	20 mM	0.1115 mL	0.5574 mL	1.1148 mL	2.7869 mL
	25 mM	0.0892 mL	0.4459 mL	0.8918 mL	2.2296 mL
	30 mM	0.0743 mL	0.3716 mL	0.7432 mL	1.8580 mL
	40 mM	0.0557 mL	0.2787 mL	0.5574 mL	1.3935 mL
	50 mM	0.0446 mL	0.2230 mL	0.4459 mL	1.1148 mL
	60 mM	0.0372 mL	0.1858 mL	0.3716 mL	0.9290 mL
	80 mM	0.0279 mL	0.1393 mL	0.2787 mL	0.6967 mL
	100 mM	0.0223 mL	0.1115 mL	0.2230 mL	0.5574 mL