Beclometasone dipropionate monohydrate
Based on 4 publication(s) in Google Scholar
Beclometasone dipropionate monohydrate, the proagent of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate monohydrate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate monohydrate can be used for asthma .
For research use only. We do not sell to patients.
- CAS No.: 77011-63-3
- Formula: C28H39ClO8
- Molecular Weight:539.06
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Beclometasone dipropionate monohydrate
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Biological Activity
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iNOS |
Beclometasone dipropionate monohydrate (1-100 nM; 20 min) inhibits STAT-1 expression and reduces the levels of iNOS, ROS and NT generated by rhIL-17A in 16HBE cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:16HBE cells
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Concentration:1, 10 and 100 nM
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Incubation Time:20 min
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Result:Reduced the levels of iNOS, ROS and NT generated by rhIL-17A.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male BALB/c mice with asthma[1]
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Dosage:150 µg/kg
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Administration:Nebulization
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Result:Decreased total cell number and relative eosinophil number in BALF.
Chemical Information
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CAS No. 77011-63-3
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Molecular Weight 539.06
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Formula C28H39ClO8
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SMILES
CCC(OCC([C@@]1([C@@]2([C@@]([C@@]3([H])[C@]([C@H](C2)O)([C@@]4(C(CC3)=CC(C=C4)=O)C)Cl)([H])C[C@@H]1C)C)OC(CC)=O)=O)=O.O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
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Journal Impact Factor
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Most Recent
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Drug Deliv Transl Res
Leveraging quantum chemical properties in transfer learning for predicting blood-brain barrier permeability of drugs. [Abstract]2025 Oct 29. PMID: 41160380 -
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Sci Total Environ
Development and validation of an activated immune model with zebrafish eleutheroembryo based on caudal fin acupuncture. [Abstract]2021 Sep 1:785:147288. PMID: 33930807 -
Purity & Documentation
References
[1]. Hrvacić B, et, al. Applicability of an ultrasonic nebulization system for the airways delivery of beclomethasone dipropionate in a murine model of asthma. Pharm Res. 2006 Aug;23(8):1765-75. [Content Brief]
[2]. Montalbano AM, et, al. Beclomethasone dipropionate and formoterol reduce oxidative/nitrosative stress generated by cigarette smoke extracts and IL-17A in human bronchial epithelial cells. Eur J Pharmacol. 2013 Oct 15;718(1-3):418-27. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Beclometasone dipropionate monohydrate Related Classifications
HY-13571B Related Classifications
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