1. GPCR/G Protein
  2. Glucocorticoid Receptor
  3. Glucocorticoid receptor agonist

Glucocorticoid receptor agonist 

Cat. No.: HY-14234 Purity: 98.57%
Handling Instructions

Glucocorticoid receptor agonist is a potent Glucocorticoid receptor agonist.

For research use only. We do not sell to patients.

Glucocorticoid receptor agonist Chemical Structure

Glucocorticoid receptor agonist Chemical Structure

CAS No. : 1245526-82-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 421 In-stock
Estimated Time of Arrival: December 31
5 mg USD 383 In-stock
Estimated Time of Arrival: December 31
10 mg USD 726 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Description

Glucocorticoid receptor agonist is a potent Glucocorticoid receptor agonist. IC50 value: Target:

Molecular Weight

396.38

Formula

C₂₀H₂₀F₄N₂O₂

CAS No.

1245526-82-2

SMILES

OC1=CC=C(C=C1C(C)(C[[email protected]](O)(C(F)(F)F)CC2=CC3=C(C=NC=C3)N2)C)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (252.28 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5228 mL 12.6142 mL 25.2283 mL
5 mM 0.5046 mL 2.5228 mL 5.0457 mL
10 mM 0.2523 mL 1.2614 mL 2.5228 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.31 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.31 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.31 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration

Animal administration [1] Female Balb/c mice weighing approximately 20 g were used. Mice were administered the test compound and in Cremophor (po) approximately 60 min prior to LPS/D-gal administration. The volume of oral gavage was 0.15 mL. Then mice were administered LPS (E. coli LPS 055:85, 1.0 μg/mouse) plus D-gal (50 mg/kg) intravenously in 0.2 mL of pyrogen-free saline. One hour after LPS/D-gal, each mouse was anesthetized, bled by cardiac puncture, and collected for serum TNF-R and compound levels. Blood samples were centrifuged at 2500 rpm for 10-15 min, the serum was decanted, and samples were stored frozen at -70°C until transfer either for TNF-R determination or to Drug Metabolism and Pharmacokinetics for plasma concentration analysis by HPLC. The concentration of TNF-R in the serum was measured by a commercially available ELISA kit. ELISA was performed. All samples are assayed in duplicate.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Product Name:
Glucocorticoid receptor agonist
Cat. No.:
HY-14234
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