1. GPCR/G Protein
  2. Glucocorticoid Receptor
  3. Glucocorticoid receptor agonist

Glucocorticoid receptor agonist 

Cat. No.: HY-14234 Purity: 98.57%
Handling Instructions

Glucocorticoid receptor agonist is a potent Glucocorticoid receptor agonist.

For research use only. We do not sell to patients.

Glucocorticoid receptor agonist Chemical Structure

Glucocorticoid receptor agonist Chemical Structure

CAS No. : 1245526-82-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 421 In-stock
Estimated Time of Arrival: December 31
5 mg USD 383 In-stock
Estimated Time of Arrival: December 31
10 mg USD 726 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Top Publications Citing Use of Products
  • Biological Activity

  • Protocol

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Description

Glucocorticoid receptor agonist is a potent Glucocorticoid receptor agonist. IC50 value: Target:

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (252.28 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5228 mL 12.6142 mL 25.2283 mL
5 mM 0.5046 mL 2.5228 mL 5.0457 mL
10 mM 0.2523 mL 1.2614 mL 2.5228 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.31 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.31 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.31 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration

Animal administration [1] Female Balb/c mice weighing approximately 20 g were used. Mice were administered the test compound and in Cremophor (po) approximately 60 min prior to LPS/D-gal administration. The volume of oral gavage was 0.15 mL. Then mice were administered LPS (E. coli LPS 055:85, 1.0 μg/mouse) plus D-gal (50 mg/kg) intravenously in 0.2 mL of pyrogen-free saline. One hour after LPS/D-gal, each mouse was anesthetized, bled by cardiac puncture, and collected for serum TNF-R and compound levels. Blood samples were centrifuged at 2500 rpm for 10-15 min, the serum was decanted, and samples were stored frozen at -70°C until transfer either for TNF-R determination or to Drug Metabolism and Pharmacokinetics for plasma concentration analysis by HPLC. The concentration of TNF-R in the serum was measured by a commercially available ELISA kit. ELISA was performed. All samples are assayed in duplicate.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

396.38

Formula

C₂₀H₂₀F₄N₂O₂

CAS No.

1245526-82-2

SMILES

OC1=CC=C(C=C1C(C)(C[[email protected]](O)(C(F)(F)F)CC2=CC3=C(C=NC=C3)N2)C)F

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Glucocorticoid receptor agonist
Cat. No.:
HY-14234
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Glucocorticoid receptor agonist

Cat. No.: HY-14234