1. GPCR/G Protein
  2. Glucocorticoid Receptor
  3. Desonide

Desonide 

Cat. No.: HY-B0248 Purity: 99.81%
Handling Instructions

Desonide is a nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses.

For research use only. We do not sell to patients.

Desonide Chemical Structure

Desonide Chemical Structure

CAS No. : 638-94-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 90 In-stock
Estimated Time of Arrival: December 31
100 mg USD 120 In-stock
Estimated Time of Arrival: December 31
200 mg USD 180 In-stock
Estimated Time of Arrival: December 31
500 mg USD 360 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Desonide is a nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses. Target: Glucocorticoid Receptor Desonide is a low-potency topical corticosteroid that has been used for decades in the treatment of steroid-responsive dermatoses [1]. Desonide induced significant colorimetric improvement compared with placebo. A good to excellent response was achieved in 30% for desonide, and 6% for placebo. Decreased pigmentation in the desonide-treated axillae was associated with recovery of disruption at the basal membrane. Desonide showed depigmenting properties in women with axillary hyperpigmentation [2]. Given the favorable safety profile of all other desonide preparations and their utility as a low potency corticosteroid, desonide foam promises to be a useful addition to the armamentarium, when other desonide vehicles might be less acceptable [3].

Clinical Trial
Molecular Weight

416.51

Formula

C₂₄H₃₂O₆

CAS No.

638-94-8

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (240.09 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4009 mL 12.0045 mL 24.0090 mL
5 mM 0.4802 mL 2.4009 mL 4.8018 mL
10 mM 0.2401 mL 1.2005 mL 2.4009 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3.25 mg/mL (7.80 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3.25 mg/mL (7.80 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3.25 mg/mL (7.80 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Desonide
Cat. No.:
HY-B0248
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