Betamethasone acetate
Based on 1 Customer Validation
Betamethasone acetate is a glucocorticoid with prenatal application for preventing respiratory distress syndrome (RDS) in premature infants. Betamethasone acetate exhibits dose-dependent effects on somatic and brain development in offspring when administered prenatally to pregnant rats. Betamethasone acetate can be used for the study of antenatal intervention.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.38%
- CAS No.: 987-24-6
- 화학식: C24H31FO6
- 분자량:434.50
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
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HY-77839
CortodoxoneGlucocorticoid Steroid Hormone -
HY-77839R
Cortodoxone (Standard)Glucocorticoid Steroid Hormone -
HY-13570BR
Betamethasone acetate (Standard)Glucocorticoid Corticosteroid -
HY-17463
PrednisoloneGlucocorticoid -
HY-13580
BudesonideGlucocorticoid Receptor Agonist -
HY-B0251
EplerenoneAldosterone Blocker -
HY-A0158
DiflorasoneAnti-inflammatory Steroid -
HY-13609
DeflazacortGlucocorticoid -
HY-17463R
Prednisolone (Standard) -
HY-13580R
Budesonide (Standard) -
HY-13570
BetamethasoneGlucocorticoid Receptor Agonist -
HY-B1616
Clobetasone butyrateGlucocorticoid
Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | EC50 |
4.5 μM
Compound: Dexamethasone acetate
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Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
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[PMID: 20966043] |
In Vivo
Betamethasone (170-340 μg/ kg, i.n., twice within 4 h on E20) (acetate) induces moderate dose-dependent somatic growth retardation (reduced birth weight, crown-tail length, head diameter) in offspring of pregnant Fisher 344 rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Preterm sheep (122 days of gestation)[1]
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Dosage:0.125, 0.25 mg/kg
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Administration:i.m., single dose
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Result:Improved fetal lung maturation in preterm sheep.
Increased the mRNA expression of surfactant proteins A, B, C (SFTPA, SFTPB, SFTPC), ABCA3, and AQP5 in fetal sheep lungs.
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Animal Model:3-month-old time-pregnant Fisher 344 dams[2]
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Dosage:170, 340 μg/ kg
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Administration:i.n., twice within 4 h on E20
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Result:Induced moderate dose-dependent somatic growth retardation.
Caused significant brain growth retardation in offspring.
Exhibited chronically anti-proliferative effects on brain cells.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 987-24-6
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Appearance Solid
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분자량 434.50
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화학식 C24H31FO6
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Color White to off-white
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SMILES
C[C@@]12[C@](C[C@H](C)[C@]2(O)C(COC(C)=O)=O)([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C1)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
순도&문서
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Schmidt AF, et al. Low-dose betamethasone-acetate for fetal lung maturation in preterm sheep. Am J Obstet Gynecol. 2018 Jan;218(1):132.e1-132.e9. [Content Brief]
[2]. Scheepens A, et al. A single course of prenatal betamethasone in the rat alters postnatal brain cell proliferation but not apoptosis. J Physiol. 2003 Oct 1;552(Pt 1):163-75. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Betamethasone acetate Related Classifications
HY-13570B Related Classifications
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