Betamethasone acetate
Based on 1 Customer Validation
Betamethasone acetate is a glucocorticoid with prenatal application for preventing respiratory distress syndrome (RDS) in premature infants. Betamethasone acetate exhibits dose-dependent effects on somatic and brain development in offspring when administered prenatally to pregnant rats. Betamethasone acetate can be used for the study of antenatal intervention.
For research use only. We do not sell to patients.
- Purity: 99.38%
- CAS No.: 987-24-6
- Formula: C24H31FO6
- Molecular Weight:434.50
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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HY-77839
Cortodoxone
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HY-77839R
Cortodoxone (Standard)
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HY-13570BR
Betamethasone acetate (Standard)
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Diflorasone
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HY-13609
Deflazacort
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HY-17463R
Prednisolone (Standard)
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HY-13580R
Budesonide (Standard)
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HY-13570
Betamethasone
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HY-B1616
Clobetasone butyrate
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | EC50 |
4.5 μM
Compound: Dexamethasone acetate
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Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
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[PMID: 20966043] |
Betamethasone (170-340 μg/ kg, i.n., twice within 4 h on E20) (acetate) induces moderate dose-dependent somatic growth retardation (reduced birth weight, crown-tail length, head diameter) in offspring of pregnant Fisher 344 rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Preterm sheep (122 days of gestation)[1]
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Dosage:0.125, 0.25 mg/kg
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Administration:i.m., single dose
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Result:Improved fetal lung maturation in preterm sheep.
Increased the mRNA expression of surfactant proteins A, B, C (SFTPA, SFTPB, SFTPC), ABCA3, and AQP5 in fetal sheep lungs.
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Animal Model:3-month-old time-pregnant Fisher 344 dams[2]
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Dosage:170, 340 μg/ kg
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Administration:i.n., twice within 4 h on E20
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Result:Induced moderate dose-dependent somatic growth retardation.
Caused significant brain growth retardation in offspring.
Exhibited chronically anti-proliferative effects on brain cells.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 987-24-6
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Appearance Solid
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Molecular Weight 434.50
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Formula C24H31FO6
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Color White to off-white
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SMILES
C[C@@]12[C@](C[C@H](C)[C@]2(O)C(COC(C)=O)=O)([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Schmidt AF, et al. Low-dose betamethasone-acetate for fetal lung maturation in preterm sheep. Am J Obstet Gynecol. 2018 Jan;218(1):132.e1-132.e9. [Content Brief]
[2]. Scheepens A, et al. A single course of prenatal betamethasone in the rat alters postnatal brain cell proliferation but not apoptosis. J Physiol. 2003 Oct 1;552(Pt 1):163-75. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Betamethasone acetate Related Classifications
HY-13570B Related Classifications
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