Betamethasone acetate-d5
Betamethasone acetate-d5 is deuterium labeled Betamethasone acetate (HY-13570B). Betamethasone acetate is a glucocorticoid with prenatal application for preventing respiratory distress syndrome (RDS) in premature infants. Betamethasone acetate exhibits dose-dependent effects on somatic and brain development in offspring when administered prenatally to pregnant rats. Betamethasone acetate can be used for the study of antenatal intervention.
For research use only. We do not sell to patients.
- Formula: C24H26D5FO6
- Molecular Weight:439.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Betamethasone (170-340 μg/ kg, i.n., twice within 4 h on E20) (acetate) induces moderate dose-dependent somatic growth retardation (reduced birth weight, crown-tail length, head diameter) in offspring of pregnant Fisher 344 rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Preterm sheep (122 days of gestation)[1]
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Dosage:0.125, 0.25 mg/kg
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Administration:i.m., single dose
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Result:Improved fetal lung maturation in preterm sheep.
Increased the mRNA expression of surfactant proteins A, B, C (SFTPA, SFTPB, SFTPC), ABCA3, and AQP5 in fetal sheep lungs.
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Animal Model:3-month-old time-pregnant Fisher 344 dams[2]
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Dosage:170, 340 μg/ kg
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Administration:i.n., twice within 4 h on E20
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Result:Induced moderate dose-dependent somatic growth retardation.
Caused significant brain growth retardation in offspring.
Exhibited chronically anti-proliferative effects on brain cells.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 987-24-6
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Molecular Weight 439.53
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Formula C24H26D5FO6
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SMILES
C[C@@]12[C@](C[C@@H]([C@]2(O)C(COC(C)=O)=O)C)([H])[C@@]3([H])[C@@]([C@@]4(C(C([2H])C3)=C([2H])C(C=C4)=O)C)([C@@](C1([2H])[2H])([2H])O)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Scheepens A, et al. A single course of prenatal betamethasone in the rat alters postnatal brain cell proliferation but not apoptosis. J Physiol. 2003 Oct 1;552(Pt 1):163-75. [Content Brief]
[2]. Schmidt AF, et al. Low-dose betamethasone-acetate for fetal lung maturation in preterm sheep. Am J Obstet Gynecol. 2018 Jan;218(1):132.e1-132.e9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Betamethasone acetate-d5 Related Classifications
HY-13570BS1 Related Classifications
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