Betamethasone disodium phosphate
Based on 1 Customer Validation
Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt; Vista-Methasone) is a corticosteroid. Betamethasone disodium phosphate is used in research related to inflammatory and immune diseases such as keloids.
For research use only. We do not sell to patients.
- Purity: 99.84%
- CAS No.: 151-73-5
- Formula: C22H28FNa2O8P
- Molecular Weight:516.40
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-B1829A
Dexamethasone phosphate disodium
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HY-13570CR
Betamethasone disodium phosphate (Standard)
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HY-17463
Prednisolone
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HY-13571
Betamethasone dipropionate
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HY-13570
Betamethasone
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HY-17463R
Prednisolone (Standard)
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HY-13570R
Betamethasone (Standard)
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HY-B0877
Halcinonide
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HY-B1183
Hydrocortisone acetate
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HY-13571R
Betamethasone dipropionate (Standard)
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HY-13571AR
Beclometasone dipropionate (Standard)
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HY-13571A
Beclometasone dipropionate
Biological Activity
Betamethasone disodium phosphate is a glucocorticoid with metabolic regulation, immunosuppressive and anti-inflammatory effects.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 151-73-5
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Appearance Solid
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Molecular Weight 516.40
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Formula C22H28FNa2O8P
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Color White to off-white
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SMILES
C[C@@]12[C@](C[C@@H]([C@]2(O)C(COP(O[Na])(O[Na])=O)=O)C)([H])[C@@]3([H])[C@@]([C@@]4(C(CC3)=CC(C=C4)=O)C)([C@H](C1)O)F
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Synonyms
Betamethasone 21-phosphate disodium salt; Vista-Methasone
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 100 mg/mL (193.65 mM; Need ultrasonic)
DMSO : 25 mg/mL (48.41 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.84 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.84 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / H2O | 1 mM | 1.9365 mL | 9.6824 mL | 19.3648 mL | 48.4121 mL |
| 5 mM | 0.3873 mL | 1.9365 mL | 3.8730 mL | 9.6824 mL | |
| 10 mM | 0.1936 mL | 0.9682 mL | 1.9365 mL | 4.8412 mL | |
| 15 mM | 0.1291 mL | 0.6455 mL | 1.2910 mL | 3.2275 mL | |
| 20 mM | 0.0968 mL | 0.4841 mL | 0.9682 mL | 2.4206 mL | |
| 25 mM | 0.0775 mL | 0.3873 mL | 0.7746 mL | 1.9365 mL | |
| 30 mM | 0.0645 mL | 0.3227 mL | 0.6455 mL | 1.6137 mL | |
| 40 mM | 0.0484 mL | 0.2421 mL | 0.4841 mL | 1.2103 mL | |
| H2O | 50 mM | 0.0387 mL | 0.1936 mL | 0.3873 mL | 0.9682 mL |
| 60 mM | 0.0323 mL | 0.1614 mL | 0.3227 mL | 0.8069 mL | |
| 80 mM | 0.0242 mL | 0.1210 mL | 0.2421 mL | 0.6052 mL | |
| 100 mM | 0.0194 mL | 0.0968 mL | 0.1936 mL | 0.4841 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Betamethasone disodium phosphate Related Classifications
HY-13570C Related Classifications
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