LNP Antibody (YA6639)
(Synonyms: lnp antibody; LNP_HUMAN antibody; Protein lunapark antibody; Endoplasmic reticulum junction formation protein lunapark ER junction formation factor lunapark LNPK KIAA1715 LNP)LNP Antibody (YA6639) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LNP.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000 | 1:500-1:2000 |
Product Details
LNP Antibody (YA6639) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LNP.
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Host Mouse
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 55 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 48 kDa
Recombinant protein within mouse LNP aa 198-425 / 425.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
LNP is an Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network. May be involved in limb development. Is involved in central nervous system development[1][2][3][4][5].
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Subcellular Localization
Endoplasmic reticulum membrane
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Expression
Tissue_Specificity: Expressed in neural precursor cells, where it is detected at the growth-cone-like structure and branching sites of neurite-like processes -
Isoforms & Post-Translational Modification
Q9C0E8 has four isomers: Q9C0E8-1: 47740 Da (predicted); Q9C0E8-2: 47094 Da (predicted); Q9C0E8-3: 33001 Da (predicted); Q9C0E8-4: 50848 Da (predicted).
Myristoylated; myristoylation is necessary for the endoplasmic reticulum (ER) three-way ER tubular junction formation, but is not required neither for membrane translocation, membrane topology formation, nor for the specific localization to ER membranes (PubMed:24223779)丨Phosphorylated丨Subject to proteasomal degradation following phosphorylation during mitosis (PubMed:27619977) -
Subunit
Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner (PubMed:27619977)
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SwissProt ID
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Synonyms
lnp antibody; LNP_HUMAN antibody; Protein lunapark antibody; Endoplasmic reticulum junction formation protein lunapark ER junction formation factor lunapark LNPK KIAA1715 LNP
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