LNP Antibody (YA6639)

Cat. No.: HY-P86946: Data Sheet User Guide for Antibodies
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LNP Antibody (YA6639) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LNP.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

LNP Antibody (YA6639) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LNP.

Host

Mouse

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 48 kDa;

Observed band size: 55 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9C0E8

Gene ID

80856 [NCBI]

Immunogen

Recombinant protein within mouse LNP aa 198-425 / 425.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:500-1:2000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology (PubMed:30032983). Involved in the stabilization of nascent three-way ER tubular junctions within the ER network (PubMed:24223779, PubMed:25404289, PubMed:25548161, PubMed:27619977). May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network (PubMed:25404289). May be involved in limb development (By similarity). Is involved in central nervous system development (PubMed:30032983)

Subcellular Localization：Endoplasmic reticulum membrane

Expression：
Tissue_Specificity: Expressed in neural precursor cells, where it is detected at the growth-cone-like structure and branching sites of neurite-like processes

Isoforms & Post-Translational Modification：Q9C0E8 has four isomers: Q9C0E8-1: 47740 Da (predicted); Q9C0E8-2: 47094 Da (predicted); Q9C0E8-3: 33001 Da (predicted); Q9C0E8-4: 50848 Da (predicted).
Myristoylated; myristoylation is necessary for the endoplasmic reticulum (ER) three-way ER tubular junction formation, but is not required neither for membrane translocation, membrane topology formation, nor for the specific localization to ER membranes (PubMed:24223779)丨Phosphorylated丨Subject to proteasomal degradation following phosphorylation during mitosis (PubMed:27619977)

Subunit：Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner (PubMed:27619977)

Synonyms

lnp antibody; LNP_HUMAN antibody; Protein lunapark antibody; Endoplasmic reticulum junction formation protein lunapark ER junction formation factor lunapark LNPK KIAA1715 LNP

Documentation

User Guide for Antibodies (1077 KB)