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Cat. No.: HY-156630A

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Ionizable lipid-1 hydrochloride

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure.

For research use only. We do not sell to patients.

Formula: C₅₈H₁₁₅ClN₂O₅
Molecular Weight:956.00

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

Ionizable lipid-1 hydrochloride Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure^[1].

In Vitro

Ionizable lipid-1 hydrochloride can be protonated and positively charged at acidic pH. Ionizable lipid-1 hydrochloride electrostatically binds to negatively charged RNA molecules, thereby encapsulating RNA into nanoparticles. Ionizable lipid-1 hydrochloride will be protonated again once entering cells, interacts with the negatively charged endosome membrane. The interaction leads to the disruption of the endosome membrane, thereby releasing the RNA payload into the cytoplasm^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 956.00
Formula C₅₈H₁₁₅ClN₂O₅
SMILES

[H]Cl.O=C(CCCCCCCCC(CCCCCCCCC(OC(CCCCCC)CCCCCC)=O)N(CCCN(C)C)C(CCCCCCC)=O)OC(CCCCCC)CCCCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Mol Ther

Sleeping Beauty mRNA-LNP enables stable rAAV transgene expression in mouse and NHP hepatocytes and improves vector potency. [Abstract]

2024 Oct 2;32(10):3356-3371. PMID: 38981468

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Thomas D Madden, et al. Lamellar lipid nanoparticles. Patent WO2019089828A1.

[2]. Ramaswamy S, et al., Systemic delivery of factor IX messenger RNA for protein replacement therapy. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1941-E1950. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Ionizable lipid-1 hydrochloride

1 Cited Publications

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Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References

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Ionizable lipid-1 hydrochloride

Publications Citing Use of MedChemExpress (MCE) Ionizable lipid-1 hydrochloride

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

Ionizable lipid-1 hydrochloride Related Classifications

HY-156630A Related Classifications