Ionizable lipid-1
Based on 1 publication(s) in Google Scholar
Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure.
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- Reinheit: 98.0%
- CAS. Nr.: 2055939-68-7
- Formel: C58H114N2O5
- Molecular Weight:919.54
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Speicherung:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
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Publications Citing Use of MedChemExpress (MCE) Ionizable lipid-1
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Biologische Aktivität
Ionizable lipid-1 can be protonated and positively charged at acidic pH. Ionizable lipid-1 electrostatically binds to negatively charged RNA molecules, thereby encapsulating RNA into nanoparticles. Ionizable lipid-1 will be protonated again once entering cells, interacts with the negatively charged endosome membrane. The interaction leads to the disruption of the endosome membrane, thereby releasing the RNA payload into the cytoplasm[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2055939-68-7
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Appearance Liquid (Density: 0.914±0.06 g/cm3)
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Molecular Weight 919.54
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Formel C58H114N2O5
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Color Colorless to light yellow
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SMILES
O=C(CCCCCCCCC(CCCCCCCCC(OC(CCCCCC)CCCCCC)=O)N(CCCN(C)C)C(CCCCCCC)=O)OC(CCCCCC)CCCCCC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Mol Ther
Sleeping Beauty mRNA-LNP enables stable rAAV transgene expression in mouse and NHP hepatocytes and improves vector potency. [Abstract]2024 Oct 2;32(10):3356-3371. PMID: 38981468
Lösungsmittel & Löslichkeit
Methanol : 50 mg/mL (54.38 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| Methanol | 1 mM | 1.0875 mL | 5.4375 mL | 10.8750 mL | 27.1875 mL |
| 5 mM | 0.2175 mL | 1.0875 mL | 2.1750 mL | 5.4375 mL | |
| 10 mM | 0.1088 mL | 0.5438 mL | 1.0875 mL | 2.7188 mL | |
| 15 mM | 0.0725 mL | 0.3625 mL | 0.7250 mL | 1.8125 mL | |
| 20 mM | 0.0544 mL | 0.2719 mL | 0.5438 mL | 1.3594 mL | |
| 25 mM | 0.0435 mL | 0.2175 mL | 0.4350 mL | 1.0875 mL | |
| 30 mM | 0.0363 mL | 0.1813 mL | 0.3625 mL | 0.9063 mL | |
| 40 mM | 0.0272 mL | 0.1359 mL | 0.2719 mL | 0.6797 mL | |
| 50 mM | 0.0218 mL | 0.1088 mL | 0.2175 mL | 0.5438 mL |
Ionizable lipid-1 Related Classifications
HY-156630 Related Classifications
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