2. Metabolic Enzyme/Protease
  3. Liposome
  4. LCA-H10

LCA-H10 is a lithocholic acid-histidine decapeptide conjugate, a biocompatible lipid nanoparticle (LNP) additive that reduces ionizable lipid proportions, functions as an endosomal escape inducer, and enhances siRNA encapsulation. LCA-H10 increases hepatic accumulation of LNPs in mice after intravenous injection when incorporated into LiLNP-LH and reduces proinflammatory cytokines (IL-6, TNF, IL-1β) in mouse serum. LCA-H10 can be used for the research of prostate cancer.

For research use only. We do not sell to patients.

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LCA-H10

LCA-H10 Chemical Structure

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LCA-H10 Related Antibodies

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Description

LCA-H10 is a lithocholic acid-histidine decapeptide conjugate, a biocompatible lipid nanoparticle (LNP) additive that reduces ionizable lipid proportions, functions as an endosomal escape inducer, and enhances siRNA encapsulation. LCA-H10 increases hepatic accumulation of LNPs in mice after intravenous injection when incorporated into LiLNP-LH and reduces proinflammatory cytokines (IL-6, TNF, IL-1β) in mouse serum. LCA-H10 can be used for the research of prostate cancer[1].

In Vitro

LiLNP-LH (containing LCA-H10) (0-187.8 nM siRNA; 5 h + 43 h) provided enhanced gene silencing activity in PC3-GFP cells compared to LiLNP and LiLNP-H, with an IC50 of 216.9 nM[1].
LiLNP-LH (containing LCA-H10) (0.3 μg/mL siRNA (PC3); 1.5 μg/mL siRNA (HepG2); 5-6 h) showed comparable intracellular uptake to HiLNP in HepG2 cells and similar uptake to LiLNP in PC3 cells[1].
LiLNP-LH (containing LCA-H10) (0.9% molar ratio) achieved high siRNA encapsulation efficiency (83.7%) comparable to HiLNP despite a low ionizable lipid proportion[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LCA-H10 Related Antibodies
In Vivo

LiLNP-LH (40 μg-2 mg/kg siRNA; i.v.) enhances liver accumulation 1.6-fold and reduces inflammatory cytokine induction by 15-30-fold compared to HiLNPs in healthy C57BL/6 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (6 weeks old, female)[1]
Dosage: 40 μg siRNA per mouse (biodistribution); 2 mg/kg siRNA (cytokine analysis)
Administration: i.v.
Result: Exhibited 4.6× 10¹⁰ total flux in the liver (1.6-fold higher than HiLNPs) and 50.4 × 10² RFI/mg organ in liver homogenates. Reduced serum IL-6 levels to 144.1 pg/mL (30.6-fold lower than HiLNPs), TNF levels by 29.9-fold, and IL-1β levels by 14.5-fold compared to HiLNPs.
Molecular Weight

1747.97

Formula

C84H110N30O13
Sequence

LCA-His-His-His-His-His-His-His-His-His-His
Sequence Shortening

LCA-HHHHHHHHHH
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LCA-H10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LCA-H10Liposomeendosomal escape inducerprostate cancerHepG2 cellsendosomal membrane destabilizationlipid nanoparticlesiRNAproinflammatory cytokinesmicellar structurescytoplasmPC3-GFP cellsInhibitorinhibitorinhibit

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