DSPE-PEG5000-DBCO
Based on 1 Customer Validation
DSPE-PEG5000-DBCO is a phospholipid PEG polymer that combines a hydrophobic phospholipid (DSPE), a hydrophilic polyethylene glycol spacer with a molecular weight of 5000 Da, and a reactive click chemistry terminal group (DBCO). DSPE-PEG-DBCO migrates to lymph nodes via the endogenous albumin transport system, implants bioorthogonal DBCO docking sites, and enables the enrichment of azide-functionalized vesicles in lymph nodes mediated by click chemistry. DSPE-PEG-DBCO can be used in studies related to atherosclerosis.
For research use only. We do not sell to patients.
- Purity: 87.51%
- Molecular Weight:5000 (Average)
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
DSPE-PEG2000-DBCO can be designed as the first dose (pretargeting anchor) of the two-component sonodynamic vaccine SenoVac: it efficiently migrates into lymph nodes via hitchhiking on endogenous albumin, pre-installs bioorthogonal DBCO docking sites in lymph nodes, and specifically and durably locks the azide-modified SCAV in lymph nodes through copper-free click chemistry when the second dose arrives[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
DSPE-PEG2000-DBCO (s.c.; single dose) achieves effective and sustained lymph node labeling, with fluorescence peaking at 24 hours and remaining detectable for up to 120 hours[1].
DSPE-PEG2000-DBCO (s.c.; administered prior to each vaccination dose) as part of the SenoVac platform reduces plaque senescent cell burden and attenuates atherosclerosis progression in high-fat diet-fed ApoE-/- mice[1].
DSPE-PEG2000-DBCO (s.c.; administered prior to N3-SCAVᴴᴿ) as part of the SenoVac platform reduces senescent cell burden across multiple organs in p16-tdTomato reporter mice, with efficacy enhanced by ultrasound stimulation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6 (male, 6-8-week-old)[1]
-
Dosage:60 nmol
-
Administration:s.c.; single dose
-
Result:Exhibited approximately threefold higher lymph node fluorescence than DSPE-PEG-pretreated controls.
Showed strong fluorescence localized predominantly in draining lymph nodes, with moderate liver uptake and minimal signal in heart, spleen, lung, and kidney.
Chemical Information
-
Appearance Solid
-
Molecular Weight 5000 (Average)
-
Color Light yellow to yellow
-
SMILES
CCCCCCCCCCCCCCCCCC(OC[C@](OC(CCCCCCCCCCCCCCCCC)=O)([H])COP(O)(OCCNC(OCCNC(CCCCC(N1C(C=CC=C2)=C2C#CC(C=CC=C3)=C3C1)=O)=O)=O)=O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 10 mg/mL (Need ultrasonic)
Purity & Documentation
-
Data Sheet (268 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DSPE-PEG5000-DBCO Related Classifications
HY-W440835E Related Classifications
Powered by Bioz