4A3-Cit
Based on 1 publication(s) in Google Scholar
4A3-Cit is an ionizable lipid used for the generation of lipid nanoparticles (LNPs).
For research use only. We do not sell to patients.
- Purity: 98.04%
- CAS No.: 2768211-13-6
- Formula: C83H147N3O16S4
- Molecular Weight:1571.33
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 4A3-Cit
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Biological Activity
4A3-Cit can undergo lipid fusion with endosomal membranes within the model, thereby facilitating endosomal escape. 4A3-Cit can enhance the efficiency of in vivo mRNA delivery through Selective Organ Targeting (SORT)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2768211-13-6
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Appearance Oil
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Molecular Weight 1571.33
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Formula C83H147N3O16S4
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Color Colorless to light yellow
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SMILES
O=C(CCN(CCCN(CCCN(CCC(OCCOC(C(CSCCC(CC/C=C(C)/C)C)C)=O)=O)CCC(OCCOC(C(CSCCC(CC/C=C(C)/C)C)C)=O)=O)C)CCC(OCCOC(C(CSCCC(CC/C=C(C)/C)C)C)=O)=O)OCCOC(C(CSCCC(CC/C=C(C)\C)C)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Mol Ther
2026 Mar 3:S1525-0016(26)00178-4. PMID: 41782368
Solvent & Solubility
DMSO : 100 mg/mL (63.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6364 mL | 3.1820 mL | 6.3640 mL | 15.9101 mL |
| 5 mM | 0.1273 mL | 0.6364 mL | 1.2728 mL | 3.1820 mL | |
| 10 mM | 0.0636 mL | 0.3182 mL | 0.6364 mL | 1.5910 mL | |
| 15 mM | 0.0424 mL | 0.2121 mL | 0.4243 mL | 1.0607 mL | |
| 20 mM | 0.0318 mL | 0.1591 mL | 0.3182 mL | 0.7955 mL | |
| 25 mM | 0.0255 mL | 0.1273 mL | 0.2546 mL | 0.6364 mL | |
| 30 mM | 0.0212 mL | 0.1061 mL | 0.2121 mL | 0.5303 mL | |
| 40 mM | 0.0159 mL | 0.0796 mL | 0.1591 mL | 0.3978 mL | |
| 50 mM | 0.0127 mL | 0.0636 mL | 0.1273 mL | 0.3182 mL | |
| 60 mM | 0.0106 mL | 0.0530 mL | 0.1061 mL | 0.2652 mL |
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