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  4. ppTG21

ppTG21 is an endosomolytic agent and inducer. ppTG21 can facilitate endosomal escape of Cas9-2lig-1NLS and Cas9-ASGPrL ribonucleoproteins (RNPs) to enable receptor-facilitated, cell-type specific gene editing in cancer cells without electroporation or transfection reagents. ppTG21 can be used for the research of gene editing.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

ppTG21

ppTG21 Chemical Structure

CAS No. : 380480-77-3

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ppTG21 Related Antibodies

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Description

ppTG21 is an endosomolytic agent and inducer. ppTG21 can facilitate endosomal escape of Cas9-2lig-1NLS and Cas9-ASGPrL ribonucleoproteins (RNPs) to enable receptor-facilitated, cell-type specific gene editing in cancer cells without electroporation or transfection reagents. ppTG21 can be used for the research of gene editing[1].

In Vitro

ppTG21 (7.5 nmol ppTG21 salt; 44-48 h) facilitates endosomal escape of Cas9-2lig-1NLS RNP, leading to cell-type specific gene editing with 4.8% indels in HEPG2 cells (ASGPr+); negligible editing occurs in SKHEP cells (ASGPr diminished) with either RNP[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ppTG21 Related Antibodies
Molecular Weight

2341.80

Formula

C115H173N31O22
CAS No.
Sequence

Gly-Leu-Phe-His-Ala-Leu-Leu-His-Leu-Leu-His-Ser-Leu-Trp-His-Leu-Leu-Leu-His-Ala
Sequence Shortening

GLFHALLHLLHSLWHLLLHA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ppTG21 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ppTG21380480-77-3ppTG 21ppTG-21Biochemical Assay ReagentsRNPsSKHEP cellsendosomolytic agentcell-type specific gene editingCas9-2lig-1NLSASGPr+ASGPr diminishedreceptor-facilitatedHEPG2 cellscancer cellsendosomal escapeCas9-ASGPrL ribonucleoproteinsinducerInhibitorinhibitorinhibit

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ppTG21
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HY-P11639
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