L-Glutamine GMP is L-Glutamine (HY-N0390) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
For research use only. We do not sell to patients.
- CAS No.: 56-85-9
- Formula: C5H10N2O3
- Molecular Weight:146.14
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
mTORC1 |
STAT3 |
HIF-1α |
L-Glutamine (GMP) is essential for osteoclast differentiation, maturation, and bone-resorbing activity via SLC1A5-mediated uptake and conversion to α-KG for anaplerosis, with hypoxia-stimulated uptake supporting biosynthetic needs[1].
L-Glutamine (GMP) promotes BMSC proliferation via upregulation of cell cycle regulators, activation of GLS and GDH through mTOR/S6 and MAPK pathways, and amino acid transaminase-dependent α-KG production[1].
L-Glutamine (GMP) promotes BMSC osteogenic differentiation via GLS-dependent TCA cycle anaplerosis, regulation by ERRα and mTOR signaling pathways, and glutathione-mediated ROS neutralization, but does not contribute to adipocytic differentiation of BMSCs[1].
L-Glutamine (GMP) (High-dose) enhances the immunosuppressive properties of BMSCs by modulating cytokine production via reduced NF-κB and increased STAT-3 activity, and inhibits lymphocyte and macrophage proliferation in coculture[1].
L-Glutamine (GMP) improves osteoblast viability, enhances glucose utilization, and promotes matrix mineralization in human osteoblast-like cell lines and mouse calvarial osteoblasts[1].
L-Glutamine (GMP) supports chondrocyte extracellular matrix synthesis, enhances hypoxia tolerance via HIF-1α/GLS1-mediated α-KG production, and protects chondrocytes from injury and apoptosis through glutathione and HSP70 upregulation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pretreatment with L-Glutamine GMP (1-2 g/kg; p.o.; once every 2 days; for 5 days) significantly attenuates Cantharidin (HY-N0209)-induced body weight loss in female BALB/c mice[4].
Pretreatment with L-Glutamine GMP (1-2 g/kg; p.o.; once every 2 days; for a total of 5 days) reduces the mortality rate of female BALB/c mice exposed to 3 mg/kg Cantharidin[4].
Pretreatment with L-Glutamine GMP (1-2 g/kg; p.o.; single dose) significantly normalizes cardiac mass index, cardiac biomarkers, oxidative stress markers, and succinate dehydrogenase activity, and alleviates histopathological damage in female BALB/c mice with acute cardiotoxicity induced by Cantharidin[4].
Pretreatment with L-Glutamine GMP (1-2 g/kg; p.o.; single dose) reduces Cantharidin-induced ST-segment elevation and alleviates myocardial injury in female BALB/c mice[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:BALB/c (female, 6 weeks old, 18 g)[4]
-
Dosage:1 g/kg; 2 g/kg
-
Administration:p.o.; once every 2 days; 5 days
-
Result:Reduced cantharidin-induced weight loss.
Showed a statistically significant protective effect at 2 g/kg dose compared to the cantharidin-only group.\nDelayed cantharidin-induced mortality.
Resulted in slower death rates compared to the cantharidin-only group over the 5-day observation period.
Chemical Information
-
CAS No. 56-85-9
-
Molecular Weight 146.14
-
Formula C5H10N2O3
-
SMILES
N[C@@H](CCC(N)=O)C(O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Zhou T, et al. Glutamine Metabolism Is Essential for Stemness of Bone Marrow Mesenchymal Stem Cells and Bone Homeostasis. Stem Cells Int. 2019;2019:8928934. Published 2019 Sep 12. [Content Brief]
[3]. Luo LL, et al. L-glutamine protects mouse brain from ischemic injury via up-regulating heat shock protein 70. CNS Neurosci Ther. 2019;25(9):1030-1041. [Content Brief]
[4]. Shao H, et al. The protective effect of L-glutamine against acute Cantharidin-induced Cardiotoxicity in the mice. BMC Pharmacol Toxicol. 2020;21(1):71. Published 2020 Oct 1. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-Glutamine (GMP) Related Classifications
HY-N0390G Related Classifications
Powered by Bioz