2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. L-Aspartic acid

L-Aspartic aicd is an amino acid. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions.

For research use only. We do not sell to patients.

CAS No. : 56-84-8

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10 mM * 1 mL in Water
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L-Aspartic acid Related Antibodies

Top Publications Citing Use of Products

    L-Aspartic acid purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 May:71:103112.  [Abstract]

    IPI-2I cells were transfected with an empty vector or the eukaryotic expression plasmid pCAGGS-Flag-SLC1A3, and then infected with PDCoV (MOI = 0.5) in glutamine-containing medium, glutamine-free medium, or glutamine-free medium supplemented with L-Aspartic acid (Asp: 4 mM) or Glu (4 mM).

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    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Purity & Documentation

    • References

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    Description

    L-Aspartic aicd is an amino acid. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions[1][2][3].

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    Cellular Effect
    Cell Line Type Value Description References
    CHO EC50
    > 1000 μM
    Compound: (S)-1
    Agonistic activity at mGlu1-alpha receptor expressed in CHO cells
    Agonistic activity at mGlu1-alpha receptor expressed in CHO cells
    		[PMID: 8759641]
    CHO EC50
    > 1000 μM
    Compound: (S)-1
    Agonistic activity at mGlu2 receptor expressed in CHO cells
    Agonistic activity at mGlu2 receptor expressed in CHO cells
    		[PMID: 8759641]
    CHO EC50
    > 1000 μM
    Compound: (S)-1
    Agonistic activity at mGlu6 receptor expressed in CHO cells
    Agonistic activity at mGlu6 receptor expressed in CHO cells
    		[PMID: 8759641]
    HEK293 EC50
    15 μM
    Compound: 5960
    Substrate uptake by the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A3 cells (PubChem AID: 1745864)
    Substrate uptake by the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A3 cells (PubChem AID: 1745864)
    		10.5281/zenodo.6782621
    HEK293 EC50
    398 μM
    Compound: L-asp
    Inhibition of the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by L-glutamate uptake in HEK-293 JumpIN-SLC1A3 cells (PubChem AID: 1745862)
    Inhibition of the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by L-glutamate uptake in HEK-293 JumpIN-SLC1A3 cells (PubChem AID: 1745862)
    		[PMID: 35677430]
    In Vivo

    L-Aspartic acid is shown to be a suitable prodrug for colon-specific drug deliverly[1]. L-[3H]Asp remaining in the brain at 5 min is increased by 206 and 178% by preadministration of 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, whereas 100 mM D-Asp does not affect L-[3H]Asp efflux transport. That value for L-[3H]Glu at 20 min is increased by 145 and 156% by coadministration with 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, but not by D-Asp. It is interesting that the apparent efflux rate of L-Aspartic acid across the BBB is sevenfold faster than that of L-Glu[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    133.10

    Formula

    C4H7NO4
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    N[C@H](C(O)=O)CC(O)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Store at room temperature 3 years

    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    1M NaOH : 100 mg/mL (751.31 mM; ultrasonic and adjust pH to 12 with NaOH)

    H2O : 2 mg/mL (15.03 mM; ultrasonic and warming and heat to 60°C)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 7.5131 mL 37.5657 mL 75.1315 mL
    5 mM 1.5026 mL 7.5131 mL 15.0263 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 1 mg/mL (7.51 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    (per animal)

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    (per animal)

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.88%

    SDS (393 KB)

    COA (248 KB) HNMR (128 KB) RP-HPLC (234 KB) MS (144 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / 1M NaOH 1 mM 7.5131 mL 37.5657 mL 75.1315 mL 187.8287 mL
    5 mM 1.5026 mL 7.5131 mL 15.0263 mL 37.5657 mL
    10 mM 0.7513 mL 3.7566 mL 7.5131 mL 18.7829 mL
    15 mM 0.5009 mL 2.5044 mL 5.0088 mL 12.5219 mL
    1M NaOH 20 mM 0.3757 mL 1.8783 mL 3.7566 mL 9.3914 mL
    25 mM 0.3005 mL 1.5026 mL 3.0053 mL 7.5131 mL
    30 mM 0.2504 mL 1.2522 mL 2.5044 mL 6.2610 mL
    40 mM 0.1878 mL 0.9391 mL 1.8783 mL 4.6957 mL
    50 mM 0.1503 mL 0.7513 mL 1.5026 mL 3.7566 mL
    60 mM 0.1252 mL 0.6261 mL 1.2522 mL 3.1305 mL
    80 mM 0.0939 mL 0.4696 mL 0.9391 mL 2.3479 mL
    100 mM 0.0751 mL 0.3757 mL 0.7513 mL 1.8783 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    L-Aspartic acid Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    L-Aspartic acid56-84-8Endogenous Metaboliteamino acidprodruginflammatoryInhibitorinhibitorinhibit

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