L-Aspartic acid

Name: L-Aspartic acid
Brand: MedChemExpress
SKU: HY-N0666
Rating: 4.5 (2 reviews)

Cat. No.: HY-N0666 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.

For research use only. We do not sell to patients.

L-Aspartic acid Chemical Structure

CAS No. : 56-84-8

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in Water ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid
500 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
1 g	USD 60	In-stock	Estimated Time of Arrival: December 31
5 g		Get quote
10 g		Get quote

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Based on 2 publication(s) in Google Scholar

Other Forms of L-Aspartic acid:

2 Publications Citing Use of MCE L-Aspartic acid

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Biological Activity
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Description

L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

In Vivo

L-Aspartic acid is shown to be a suitable prodrug for colon-specific drug deliverly^[1]. L-[³H]Asp remaining in the brain at 5 min is increased by 206 and 178% by preadministration of 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, whereas 100 mM D-Asp does not affect L-[³H]Asp efflux transport. That value for L-[³H]Glu at 20 min is increased by 145 and 156% by coadministration with 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, but not by D-Asp. It is interesting that the apparent efflux rate of L-Aspartic acid across the BBB is sevenfold faster than that of L-Glu^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

133.10

Formula

C₄H₇NO₄

CAS No.

56-84-8

Appearance

Solid

Color

White to off-white

SMILES

N[C@H](C(O)=O)CC(O)=O

Structure Classification

Amino acids

Initial Source

Microorganisms

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

1M NaOH : 100 mg/mL (751.31 mM; ultrasonic and adjust pH to 12 with NaOH)

H₂O : 2 mg/mL (15.03 mM; ultrasonic and warming and heat to 60°C)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.5131 mL	37.5657 mL	75.1315 mL
5 mM	1.5026 mL	7.5131 mL	15.0263 mL
10 mM	0.7513 mL	3.7566 mL	7.5131 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 1 mg/mL (7.51 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (0 KB)

COA (246 KB) HNMR (238 KB)

Handling Instructions (2659 KB)

References

[1]. Hosoya K, et al. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem. 1999 Sep;73(3):1206-11. [Content Brief]

[2]. Leopold CS, et al. In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery. J Pharmacokinet Biopharm. 1995 Aug;23(4):397-406. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / 1M NaOH	1 mM	7.5131 mL	37.5657 mL	75.1315 mL	187.8287 mL
	5 mM	1.5026 mL	7.5131 mL	15.0263 mL	37.5657 mL
	10 mM	0.7513 mL	3.7566 mL	7.5131 mL	18.7829 mL
	15 mM	0.5009 mL	2.5044 mL	5.0088 mL	12.5219 mL
1M NaOH	20 mM	0.3757 mL	1.8783 mL	3.7566 mL	9.3914 mL
	25 mM	0.3005 mL	1.5026 mL	3.0053 mL	7.5131 mL
	30 mM	0.2504 mL	1.2522 mL	2.5044 mL	6.2610 mL
	40 mM	0.1878 mL	0.9391 mL	1.8783 mL	4.6957 mL
	50 mM	0.1503 mL	0.7513 mL	1.5026 mL	3.7566 mL
	60 mM	0.1252 mL	0.6261 mL	1.2522 mL	3.1305 mL
	80 mM	0.0939 mL	0.4696 mL	0.9391 mL	2.3479 mL
	100 mM	0.0751 mL	0.3757 mL	0.7513 mL	1.8783 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

L-Aspartic acid Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Aspartic acid56-84-8Endogenous MetaboliteInhibitorinhibitorinhibit

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L-Aspartic acid

Customer Review

Other Forms of L-Aspartic acid:

L-Aspartic acid Related Antibodies

2 Publications Citing Use of MCE L-Aspartic acid

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

L-Aspartic acid Related Classifications

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