L-Aspartic aicd disodium
Based on 5 publication(s) in Google Scholar
L-Aspartic acid disodium (disodium L-aspartate) is a NMDA receptor agonist and acidic amino acid. L-Aspartic acid disodium has no independent analgesic activity. L-Aspartic acid disodium can antagonize the analgesic effects of D-Aspartic acid and Morphine. L-Aspartic acid disodium regulates polymorph transformation, crystal growth/aggregation and nucleation processes of calcium carbonate, and can serve as a biomineralization template. L-Aspartic acid disodium promotes burst firing of central neurons. L-Aspartic acid disodium can be used in studies related to cerebral ischemia and epilepsy.
For research use only. We do not sell to patients.
- Purity: 97.0%
- CAS No.: 5598-53-8
- Formula: C4H5NNa2O4
- Molecular Weight:177.07
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) L-Aspartic aicd disodium
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Biological Activity
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NMDA Receptor |
L-Aspartic acid (L-[3H]Asp; 0.05 μCi/mL; 1-120 min) disodium is taken up by rat brain slices, with a slice-to-medium ratio of 2.53 mL/g brain tissue at 120 minutes and an initial uptake rate of 1.22 mL/min/g brain tissue[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/C (both sexes, 25-40 g)[1]
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Dosage:55 mg/kg; 115 mg/kg; 230 mg/kg
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Administration:i.p.
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Result:Did not cause any antinociceptive effect at doses of 55, 115, and 230 mg/kg.
Significantly inhibited the antinociceptive effect of 115 mg/kg D-aspartic acid at 230 mg/kg.
Shortened the duration of the antinociceptive effect of 5 mg/kg morphine at 230 mg/kg.
Chemical Information
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CAS No. 5598-53-8
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Appearance Solid
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Molecular Weight 177.07
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Formula C4H5NNa2O4
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Color White to off-white
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SMILES
N[C@@H](CC(O[Na])=O)C(O[Na])=O
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Synonyms
Disodium L-aspartate
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (5)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Nat Protoc
2021 Jan;16(1):431-457. PMID: 33349703 -
Redox Biol
Enteric coronavirus PDCoV evokes a non-Warburg effect by hijacking pyruvic acid as a metabolic hub. [Abstract]2024 May:71:103112. PMID: 38461791
L-Aspartic aicd disodium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 May:71:103112. [Abstract]
IPI-2I cells were transfected with an empty vector or the eukaryotic expression plasmid pCAGGS-Flag-SLC1A3, and then infected with PDCoV (MOI = 0.5) in glutamine-containing medium, glutamine-free medium, or glutamine-free medium supplemented with L-Aspartic acid (Asp: 4 mM) or Glu (4 mM).
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FASEB J
Maternal LDHB Safeguards Redox Balance and Developmental Competence During Preimplantation Embryo Cleavage. [Abstract]2026 May 31;40(10):e71888. PMID: 42117986 -
Amino Acids
Identification of amino acids metabolomic profiling in human plasma distinguishes lupus nephritis from systemic lupus erythematosus. [Abstract]2024 Sep 18;56(1):56. PMID: 39292313
Solvent & Solubility
H2O : ≥ 50 mg/mL (282.37 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
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- Italian - IT (393 KB)
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- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Onat F, et al. Antinociceptive effect of D-aspartic acid in mice. Pharmacology, biochemistry, and behavior. 1995 Aug;51(4):715-9. [Content Brief]
[2]. Hosoya K, et al. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. Journal of neurochemistry. 1999 Sep;73(3):1206-11. [Content Brief]
[3]. Tong H, et al. Control over the crystal phase, shape, size and aggregation of calcium carbonate via a L-aspartic acid inducing process. Biomaterials. 2004 Aug;25(17):3923-9. [Content Brief]
[4]. MacDonald JF, et al. L-Aspartic acid induces a region of negative slope conductance in the current-voltage relationship of cultured spinal cord neurons. Brain research. 1982 Apr 08;237(1):248-53. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.6475 mL | 28.2374 mL | 56.4748 mL | 141.1871 mL |
| 5 mM | 1.1295 mL | 5.6475 mL | 11.2950 mL | 28.2374 mL | |
| 10 mM | 0.5647 mL | 2.8237 mL | 5.6475 mL | 14.1187 mL | |
| 15 mM | 0.3765 mL | 1.8825 mL | 3.7650 mL | 9.4125 mL | |
| 20 mM | 0.2824 mL | 1.4119 mL | 2.8237 mL | 7.0594 mL | |
| 25 mM | 0.2259 mL | 1.1295 mL | 2.2590 mL | 5.6475 mL | |
| 30 mM | 0.1882 mL | 0.9412 mL | 1.8825 mL | 4.7062 mL | |
| 40 mM | 0.1412 mL | 0.7059 mL | 1.4119 mL | 3.5297 mL | |
| 50 mM | 0.1129 mL | 0.5647 mL | 1.1295 mL | 2.8237 mL | |
| 60 mM | 0.0941 mL | 0.4706 mL | 0.9412 mL | 2.3531 mL | |
| 80 mM | 0.0706 mL | 0.3530 mL | 0.7059 mL | 1.7648 mL | |
| 100 mM | 0.0565 mL | 0.2824 mL | 0.5647 mL | 1.4119 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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