2. Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease PROTAC
  3. Calcium Channel iGluR Endogenous Metabolite Ligands for E3 Ligase
  4. L-Phenylalanine

L-Phenylalanine  (Synonyms: (S)-2-Amino-3-phenylpropionic acid)

Cat. No.: HY-N0215 Purity: 99.98%
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L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.

For research use only. We do not sell to patients.

CAS No. : 63-91-2

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L-Phenylalanine Related Antibodies

Top Publications Citing Use of Products

    L-Phenylalanine purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2024 Aug;14(8):3493-3512.

    Cell viability of MM cell lines after culturing for 48 hours with different concentrations of L-phenylalanine (0-100 μM) added to a phenylalanine-free medium.

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    N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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    AMPA Receptor NMDA Receptor Kainate Receptor

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    Human Endogenous Metabolite Microbial Metabolite

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    von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

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    Description

    L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

    IC50 & Target

    Microbial Metabolite

     

    NMDA Receptor

     

    Human Endogenous Metabolite

     

    In Vitro

    DAHP synthetase (DS) and chorismate mutase/prephenate dehydratase (CM/PD) are key enzymes in the L-Phenylalanine biosynthesis pathway. DS is sensitive to feedback inhibition by tyrosine, and CM/PD is subject to feedback inhibition by L-Phenylalanine[1]. L-Phenylalanine attenuates non-NMDA receptor function in cultured neurons with an IC50 of 980 μM[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    L-Phenylalanine Related Antibodies
    In Vivo

    The effects of L-Phenylalanine on NMDA-activated currents (INMDA) are studied in cultured hippocampal neurons from newborn rats using the patch-clamp technique. L-Phenylalanine specifically and reversibly attenuates INMDA in a concentration-dependent manner (IC50 of 1.71 mM). L-Phenylalanine inhibits specifically NMDAR current in hippocampal neurons by competing for the glycine-binding site[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    165.19

    Formula

    C9H11NO2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    N[C@@H](CC1=CC=CC=C1)C(O)=O
    Structure Classification
    Initial Source

    Escherichia coli
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    H2O : 6.67 mg/mL (40.38 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 6.0536 mL 30.2682 mL 60.5364 mL
    5 mM 1.2107 mL 6.0536 mL 12.1073 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 9.09 mg/mL (55.03 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.98%

    SDS (393 KB)

    COA (247 KB) LCMS (87 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 6.0536 mL 30.2682 mL 60.5364 mL 151.3409 mL
    5 mM 1.2107 mL 6.0536 mL 12.1073 mL 30.2682 mL
    10 mM 0.6054 mL 3.0268 mL 6.0536 mL 15.1341 mL
    15 mM 0.4036 mL 2.0179 mL 4.0358 mL 10.0894 mL
    20 mM 0.3027 mL 1.5134 mL 3.0268 mL 7.5670 mL
    25 mM 0.2421 mL 1.2107 mL 2.4215 mL 6.0536 mL
    30 mM 0.2018 mL 1.0089 mL 2.0179 mL 5.0447 mL
    40 mM 0.1513 mL 0.7567 mL 1.5134 mL 3.7835 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    L-Phenylalanine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    L-Phenylalanine63-91-2(S)-2-Amino-3-phenylpropionic acidCalcium ChanneliGluREndogenous MetaboliteLigands for E3 LigaseCa2+ channelsCa channelsIonotropic glutamate receptorsE3 ligase-recruiting MoietyEssentialvoltage-dependentα2δNMDAnon-NMDApostsynapticDAHPchorismatemutaseprephenateInhibitorinhibitorinhibit

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