1. Membrane Transporter/Ion Channel
  2. Calcium Channel
  3. L-Phenylalanine

L-Phenylalanine (Synonyms: (S)-2-Amino-3-phenylpropionic acid)

Cat. No.: HY-N0215 Purity: 98.06%
Handling Instructions

L-Phenylalanine is an antagonist at α2δ calcium channels with a Ki of 980 nM.

For research use only. We do not sell to patients.

L-Phenylalanine Chemical Structure

L-Phenylalanine Chemical Structure

CAS No. : 63-91-2

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10 mM * 1 mL in Water USD 66 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
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Description

L-Phenylalanine is an antagonist at α2δ calcium channels with a Ki of 980 nM. IC50 Value: 980 nM [1] Target: Calcium Channel L-Phenylalanine (LPA) is an electrically neutral amino acid, one of the twenty common amino acids used to biochemically form proteins. In the brain, L-phenylalanine is a competitive antagonist at the glycine binding site of NMDA receptor and at the glutamate binding site of AMPA receptor [2, 3]. At the glycine binding site of NMDA receptor L-phenylalanine has an apparent equilibrium dissociation constant (KB) of 573 ?M estimated by Schild regression [4] which is considerably lower than brain L-phenylalanine concentration observed in untreated human phenylketonuria [5]. L-Phenylalanine also inhibits neurotransmitter release at glutamatergic synapses in hippocampus and cortex with IC50 of 980 nM, a brain concentration seen in classical phenylketonuria, whereas D-phenylalanine has a significantly smaller effect [3].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 6.67 mg/mL (40.38 mM; Need ultrasonic)

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.0536 mL 30.2682 mL 60.5364 mL
5 mM 1.2107 mL 6.0536 mL 12.1073 mL
10 mM 0.6054 mL 3.0268 mL 6.0536 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

165.19

Formula

C₉H₁₁NO₂

CAS No.

63-91-2

SMILES

N[[email protected]@H](CC1=CC=CC=C1)C(O)=O

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Room temperature in continental US; may vary elsewhere

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Product Name:
L-Phenylalanine
Cat. No.:
HY-N0215
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L-Phenylalanine

Cat. No.: HY-N0215