1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. Calcium Channel
    iGluR
    Endogenous Metabolite
  3. L-Phenylalanine

L-Phenylalanine (Synonyms: (S)-2-Amino-3-phenylpropionic acid)

Cat. No.: HY-N0215 Purity: 99.30%
Handling Instructions

L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.

For research use only. We do not sell to patients.

L-Phenylalanine Chemical Structure

L-Phenylalanine Chemical Structure

CAS No. : 63-91-2

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Based on 1 publication(s) in Google Scholar

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Description

L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

DAHP synthetase (DS) and chorismate mutase/prephenate dehydratase (CM/PD) are key enzymes in the L-Phenylalanine biosynthesis pathway. DS is sensitive to feedback inhibition by tyrosine, and CM/PD is subject to feedback inhibition by L-Phenylalanine[1]. L-Phenylalanine attenuates non-NMDA receptor function in cultured neurons with an IC50 of 980 μM[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The effects of L-Phenylalanine on NMDA-activated currents (INMDA) are studied in cultured hippocampal neurons from newborn rats using the patch-clamp technique. L-Phenylalanine specifically and reversibly attenuates INMDA in a concentration-dependent manner (IC50 of 1.71 mM). L-Phenylalanine inhibits specifically NMDAR current in hippocampal neurons by competing for the glycine-binding site[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

165.19

Formula

C₉H₁₁NO₂

CAS No.

63-91-2

SMILES

N[[email protected]@H](CC1=CC=CC=C1)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 6.67 mg/mL (40.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.0536 mL 30.2682 mL 60.5364 mL
5 mM 1.2107 mL 6.0536 mL 12.1073 mL
10 mM 0.6054 mL 3.0268 mL 6.0536 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

L-Phenylalanine(S)-2-Amino-3-phenylpropionic acidCalcium ChanneliGluREndogenous MetaboliteCa2+ channelsCa channelsIonotropic glutamate receptorsEssentialvoltage-dependentα2δNMDAnon-NMDApostsynapticDAHPchorismatemutaseprephenateInhibitorinhibitorinhibit

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Product Name:
L-Phenylalanine
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HY-N0215
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