Diamino lipid DAL4
Diamino lipid DAL4 is diamino lipid for the preparation of lipid nanoparticles (LNPs) encapsulated with mRNAs encoding cytokines including IL-12, IL-27 and GM-CSF. Diamino lipid DAL4 delivers mRNA to tumor cells to exert anti-tumor activity.
For research use only. We do not sell to patients.
- CAS No.: 2939000-43-6
- Formula: C52H99BFN3O3
- Molecular Weight:844.17
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Diamino lipid DAL4 (DAL4-LNP) effectively delivers different mRNAs in vitro to tumor cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Diamino lipid DAL4 loaded with IL-12 mRNA and IL-27 mRNA (intratumoral injection) shows synergistic effect in suppressing tumor growth without causing systematic toxicity[1].
And also Diamino lipid DAL4 induces robust infiltration of immune effector cells, including IFN-γ and TNF-α producing natural killer cells (NK) and CD8+ T cells into tumors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2939000-43-6
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Molecular Weight 844.17
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Formula C52H99BFN3O3
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SMILES
CCCCCCCCCCCCN(CCCN(CCCCCC(NCC1=C(B(O)O)C=C(F)C=C1)=O)CCCCCCCCCCCC)CCCCCCCCCCCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Hot Topics
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Topics
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Most Recent
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Topics Lipid Nanoparticles: Key Nucleic Acid Delivery Vectors
Lipid nanoparticles (LNPs) are the most clinically advanced non-viral delivery systems for nucleic acid therapeutics and enable the in vivo delivery of mRNA, siRNA, and other genetic cargos.
2026-06-18
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Topics The Tumor Microenvironment: A Pro-Tumor Niche and Therapeutic Target in Cancer
Cancer is not a single mass of cancer cells, but a complex ecosystem, the tumor microenvironment (TME).
2025-10-23
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Diamino lipid DAL4 Related Classifications
HY-151508 Related Classifications
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