SR11237 

SR11237 GMP is SR11237 (HY-107413) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SR11237 is a RXR activator and lipid metabolism regulator that promotes the differentiation of induced neural stem cells into dopaminergic (TH-positive) neurons. SR11237 induces transcriptional regulation of lipogenic genes and cholesterol transporters, increases glycosaminoglycan release, and elevates total cellular triglyceride levels. SR11237 promotes heterodimerization of RXR with Nurr1, thereby enhancing tyrosine hydroxylase expression and facilitating dopamine release. SR11237 produces a synergistic effect when used in combination with bFGF/EGF. SR11237 is mainly used in studies related to osteoarthritis and Parkinson's disease^[1][2][3][4].

SR11237 GMP (1 μM; 7 d) promotes the induced differentiation of Nurr1-overexpressing C17.2-c42 neural stem cells co-cultured with primary ventral mesencephalic cells from E16 rats into dopaminergic (TH-positive) neurons, with up to 60% of C17.2-c42 cells exhibiting a dopaminergic phenotype^[1].
Combination treatment with SR11237 GMP (1 μM) and bFGF enhances dopamine release from dopamine neurons derived from Nurr1-overexpressing C17.2-c42 neural stem cells co-cultured with type 1 astrocytes from the ventral midbrain of P1 rats^[1].
SR11237 GMP (10 μM; 7 d) promotes adipogenic differentiation of human bone marrow mesenchymal stem cells by upregulating the expression of key adipogenic genes including FABP4, LPL, CEBPB and PPARG, as well as increasing lipid accumulation^[3].
SR11237 GMP (10 μM; 7 d) retains its adipogenic stimulatory effect in RARβ-knockdown human bone marrow mesenchymal stem cells, indicating that its adipogenic activity is independent of RARβ^[3].
SR11237 GMP (10 μM; 7 d) inhibits adipogenic differentiation of human liposarcoma SW872 cells by downregulating the expression of FABP4 and PPARG, whereas it exerts a pro-adipogenic effect in hBMSCs^[3].
The inhibitory effect of SR11237 GMP (10 μM; 7 d) on adipogenic differentiation of human liposarcoma SW872 cells is partially mediated by RARβ, as knockdown of RARβ attenuates this inhibitory effect^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SR11237 GMP (25 mg/kg; i.p.; daily from post-natal days 5 to 15) causes irregular ossification and premature closure of the growth plate^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

380.48

C₂₄H₂₈O₄

146670-40-8

CC1(C2=CC(C3(C4=CC=C(C(O)=O)C=C4)OCCO3)=CC=C2C(C)(C)CC1)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wagner J, et al. Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes. Nat Biotechnol. 1999;17(7):653-659.

  [2]. Sun M G, Ratneswaran A, Dupuis H, et al. The role of nuclear receptors liver X receptor and retinoid X receptor in murine cartilage[J]. Osteoarthritis and Cartilage, 2016, 24: S153-S154.

  [3]. Cao J, et al. Retinoids Regulate Adipogenesis Involving the TGFβ/SMAD and Wnt/β-Catenin Pathways in Human Bone Marrow Mesenchymal Stem Cells. Int J Mol Sci. 2017;18(4):842. Published 2017 Apr 15.

  [4]. Lenhard JM, et al. The RXR agonist LG100268 causes hepatomegaly, improves glycaemic control and decreases cardiovascular risk and cachexia in diabetic mice suffering from pancreatic beta-cell dysfunction. Diabetologia. 1999;42(5):545-554.

  [5]. Dupuis H, et al. Exposure to the RXR Agonist SR11237 in Early Life Causes Disturbed Skeletal Morphogenesis in a Rat Model. Int J Mol Sci. 2019;20(20):5198. Published 2019 Oct 20.  [Content Brief]