SR11237 (Synonyms: BMS-649)

Name: SR11237
Brand: MedChemExpress
SKU: HY-107413
Rating: 4.5 (1 reviews)

Cat. No.: HY-107413 Purity: 99.99%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

SR11237 (BMS-649) GMP is SR11237 (HY-107413) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SR11237 is a RXR activator and lipid metabolism regulator that promotes the differentiation of induced neural stem cells into dopaminergic (TH-positive) neurons. SR11237 induces transcriptional regulation of lipogenic genes and cholesterol transporters, increases glycosaminoglycan release, and elevates total cellular triglyceride levels. SR11237 promotes heterodimerization of RXR with Nurr1, thereby enhancing tyrosine hydroxylase expression and facilitating dopamine release. SR11237 produces a synergistic effect when used in combination with bFGF/EGF. SR11237 is mainly used in studies related to osteoarthritis and Parkinson's disease.

For research use only. We do not sell to patients.

SR11237 Chemical Structure

CAS No. : 146670-40-8

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of SR11237:

SR11237 (GMP) Get quote
SR11237 (Standard) Get quote

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RXRα RXRβ RXRγ

Biological Activity
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References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	12.6 μM Compound: 13a	Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 5 mins by HPLC analysis in presence of rat P450 reductase Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 5 mins by HPLC analysis in presence of rat P450 reductase	[PMID: 26918322]
Sf9	IC₅₀	7.8 μM Compound: 13a	Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 1 min by HPLC analysis in presence of rat P450 reductase Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 1 min by HPLC analysis in presence of rat P450 reductase	[PMID: 26918322]

In Vitro

SR11237 (1 μM; 7 d) promotes the induced differentiation of Nurr1-overexpressing C17.2-c42 neural stem cells co-cultured with primary ventral mesencephalic cells from E16 rats into dopaminergic (TH-positive) neurons, with up to 60% of C17.2-c42 cells exhibiting a dopaminergic phenotype^[1].
Combination treatment with SR11237 (1 μM) and bFGF enhances dopamine release from dopamine neurons derived from Nurr1-overexpressing C17.2-c42 neural stem cells co-cultured with type 1 astrocytes from the ventral midbrain of P1 rats^[1].
SR11237 (10 μM; 7 d) promotes adipogenic differentiation of human bone marrow mesenchymal stem cells by upregulating the expression of key adipogenic genes including FABP4, LPL, CEBPB and PPARG, as well as increasing lipid accumulation^[3].
SR11237 (10 μM; 7 d) retains its adipogenic stimulatory effect in RARβ-knockdown human bone marrow mesenchymal stem cells, indicating that its adipogenic activity is independent of RARβ^[3].
SR11237 (10 μM; 7 d) inhibits adipogenic differentiation of human liposarcoma SW872 cells by downregulating the expression of FABP4 and PPARG, whereas it exerts a pro-adipogenic effect in hBMSCs^[3].
The inhibitory effect of SR11237 (10 μM; 7 d) on adipogenic differentiation of human liposarcoma SW872 cells is partially mediated by RARβ, as knockdown of RARβ attenuates this inhibitory effect^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SR11237 (25 mg/kg; i.p.; daily from post-natal days 5 to 15) causes irregular ossification and premature closure of the growth plate^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague-Dawley rats^[2]
Dosage:	25 mg/kg
Administration:	I.p.; daily from post-natal days 5 to 15
Result:	Caused disturbed ossification and bone morphology in rats, including premature growth plate closure and infiltration of ossified tissue through the central epiphysis.

Molecular Weight

380.48

Formula

C₂₄H₂₈O₄

CAS No.

146670-40-8

Appearance

Solid

Color

White to off-white

SMILES

CC1(C2=CC(C3(C4=CC=C(C(O)=O)C=C4)OCCO3)=CC=C2C(C)(C)CC1)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 5 mg/mL (13.14 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6283 mL	13.1413 mL	26.2826 mL
5 mM	0.5257 mL	2.6283 mL	5.2565 mL
10 mM	0.2628 mL	1.3141 mL	2.6283 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 0.5 mg/mL (1.31 mM); Clear solution

This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.99%

Select Batch:

Data Sheet (285 KB) SDS (254 KB)

COA (261 KB) RP-HPLC (248 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Wagner J, et al. Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes. Nat Biotechnol. 1999;17(7):653-659.

[2]. Sun M G, et al. The role of nuclear receptors liver X receptor and retinoid X receptor in murine cartilage[J]. Osteoarthritis and Cartilage, 2016, 24: S153-S154.

[3]. Cao J, et al. Retinoids Regulate Adipogenesis Involving the TGFβ/SMAD and Wnt/β-Catenin Pathways in Human Bone Marrow Mesenchymal Stem Cells. Int J Mol Sci. 2017;18(4):842. Published 2017 Apr 15.

[4]. Lenhard JM, et al. The RXR agonist LG100268 causes hepatomegaly, improves glycaemic control and decreases cardiovascular risk and cachexia in diabetic mice suffering from pancreatic beta-cell dysfunction. Diabetologia. 1999;42(5):545-554.

[5]. Dupuis H, et al. Exposure to the RXR Agonist SR11237 in Early Life Causes Disturbed Skeletal Morphogenesis in a Rat Model. Int J Mol Sci. 2019;20(20):5198. Published 2019 Oct 20. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6283 mL	13.1413 mL	26.2826 mL	65.7065 mL
	5 mM	0.5257 mL	2.6283 mL	5.2565 mL	13.1413 mL
	10 mM	0.2628 mL	1.3141 mL	2.6283 mL	6.5706 mL

SR11237 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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SR11237 (Synonyms: BMS-649)

Customer Review

Other Forms of SR11237:

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Complete Stock Solution Preparation Table

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