1. Metabolic Enzyme/Protease
  2. RAR/RXR
  3. SR11237

SR11237 (Synonyms: BMS-649)

Cat. No.: HY-107413 Purity: >99.0%
Handling Instructions

SR11237 (BMS-649) is a potent retinoid X receptor (RXR)-selective agonist that is devoid of any RAR activity. SR11237 can cause RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element.

For research use only. We do not sell to patients.

SR11237 Chemical Structure

SR11237 Chemical Structure

CAS No. : 146670-40-8

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Description

SR11237 (BMS-649) is a potent retinoid X receptor (RXR)-selective agonist that is devoid of any RAR activity. SR11237 can cause RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element[1][2][3].

In Vitro

Using nuclear receptor co-transfection assays in COS-1 cells, that SR11237 is effective at transactivating a chloramphenicol acetyltransferase reporter gene through RXRs but not retinoic acid receptors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SR11237 (BMS-649) (25 mg/kg; i.p.; daily from post-natal days 5 to 15) causes irregular ossification and premature closure of the growth plate[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats[2]
Dosage: 25 mg/kg
Administration: I.p.; daily from post-natal days 5 to 15
Result: Caused disturbed ossification and bone morphology in rats, including premature growth plate closure and infiltration of ossified tissue through the central epiphysis.
Molecular Weight

380.48

Formula

C₂₄H₂₈O₄

CAS No.

146670-40-8

SMILES

CC1(C2=CC(C3(C4=CC=C(C(O)=O)C=C4)OCCO3)=CC=C2C(C)(C)CC1)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: >99.0%

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Keywords:

SR11237BMS-649SR 11237SR-11237BMS649BMS 649RAR/RXRRetinoic acid receptorsRetinoid X receptorsRXR/RXRhomodimerstransactivatereportergeneossificationboneInhibitorinhibitorinhibit

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SR11237
Cat. No.:
HY-107413
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