2. Metabolic Enzyme/Protease
    Vitamin D Related/Nuclear Receptor
  3. RAR/RXR
  4. PA452

PA452 

Cat. No.: HY-108522 Purity: 98.80%
COA Handling Instructions

PA452, retinoic X receptor (RXR) specific antagonist, inhibits the effect of Retinoic acid (RA) on Th1/Th2 development.

For research use only. We do not sell to patients.

PA452 Chemical Structure

PA452 Chemical Structure

CAS No. : 457657-34-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 352 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 352 In-stock
Solid
1 mg USD 105 In-stock
5 mg USD 320 In-stock
10 mg USD 512 In-stock
50 mg USD 1530 In-stock
100 mg USD 2450 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE PA452

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PA452, retinoic X receptor (RXR) specific antagonist, inhibits the effect of Retinoic acid (RA) on Th1/Th2 development[1].

In Vitro

PA452 inhibits the Troglitazone (TZ)-induced CK13 expression[2].
PA452 (0.01, 0.1, and 1 μM) inhibits RXR in normal human urothelial (NHU) cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

439.59

Appearance

Solid

Formula

C26H37N3O3
CAS No.
SMILES

O=C(C1=CN=C(N(C2=C(OCCCCCC)C=C3C(C)(C)CCC(C)(C)C3=C2)C)N=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 40 mg/mL (90.99 mM; Need ultrasonic and warming)

Ethanol : 4.4 mg/mL (10.01 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2748 mL 11.3742 mL 22.7485 mL
5 mM 0.4550 mL 2.2748 mL 4.5497 mL
10 mM 0.2275 mL 1.1374 mL 2.2748 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.69 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.69 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥99.0%

COA (252 KB) Elemental Analysis Report (110 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PA452457657-34-0PA 452PA-452RAR/RXRRetinoic acid receptorsRetinoid X receptorsretinoic XRXRTh1/Th2Inhibitorinhibitorinhibit

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