1. Metabolic Enzyme/Protease
  2. RAR/RXR
  3. LG100754

LG100754 (Synonyms: UVI 2112)

Cat. No.: HY-108523 Purity: 100.00%
Handling Instructions

LG100754 (UVI 2112) is a RXR dimers modulater. LG100754 acts as a RXR:RXR homodimer antagonist, but functions as a agonist towards RXR:PPARα and RXR:PPARγ heterodimers. LG100754 is an insulin sensitizer that functions through RXR.

For research use only. We do not sell to patients.

LG100754 Chemical Structure

LG100754 Chemical Structure

CAS No. : 180713-37-5

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Description

LG100754 (UVI 2112) is a RXR dimers modulater. LG100754 acts as a RXR:RXR homodimer antagonist, but functions as a agonist towards RXR:PPARα and RXR:PPARγ heterodimers. LG100754 is an insulin sensitizer that functions through RXR[1].

IC50 & Target

PPARα

 

PPARγ

 

In Vitro

LG100754 is a selective activator of endogenous RXR heterodimers[1].
LG100754 can also improve TNFα-mediated insulin resistance in mature adipocytes[1].
LG100754 acts as a bona fide activator of endogenous RXR:PPARγ heterodimers and regulator of insulin-dependent signaling pathways[1].

In Vivo

LG100754 (100 mg/kg) completely blocks the increase in glucose levels, suggesting that LG100754 can improve insulin resistance in vivo[1].

Molecular Weight

396.56

Formula

C₂₆H₃₆O₃

CAS No.

180713-37-5

SMILES

C/C(C1=C(OCCC)C=C2C(C)(C)CCC(C)(C)C2=C1)=C/C=C/C(C)=C/C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: 100.00%

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Keywords:

LG100754UVI 2112LG 100754LG-100754UVI2112UVI-2112RAR/RXRRetinoic acid receptorsRetinoid X receptorsRXR:RXRRXR:PPARαRXR:PPARγinsulinsensitizediabeticInhibitorinhibitorinhibit

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LG100754
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