CKK-E12
Based on 5 publication(s) in Google Scholar
CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based research. CKK-E12 is highly selective toward liver parenchymal cell in vivo,
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 1432494-65-9
- Formula: C60H120N4O6
- Molecular Weight:993.62
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Lipid Compound Library
HY-L043
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Liposome Library
HY-L214
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Ionizable Lipid Compound Library
HY-L251
Publications Citing Use of MedChemExpress (MCE) CKK-E12
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1432494-65-9
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Appearance Liquid (Density: 0.963±0.06 g/cm3)
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Molecular Weight 993.62
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Formula C60H120N4O6
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Color Colorless to light yellow
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SMILES
O=C(C(CCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)N1)NC(CCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)C1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (5)
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Journal Impact Factor
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Most Recent
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Nat Commun
Boosting RNA nanotherapeutics with V-ATPase activating non-inflammatory lipid nanoparticles to treat chronic lung injury. [Abstract]2025 Jul 14;16(1):6477. PMID: 40659631 -
J Am Chem Soc
Safe and Highly Efficient Lipid-Pro-Dexamethasone Nanoparticles for mRNA Delivery and Base Editing. [Abstract]2026 Mar 11;148(9):10225-10240. PMID: 41733506 -
Cell Rep Methods
A fluorescent splice-switching mouse model enables high-throughput, sensitive quantification of antisense oligonucleotide delivery and activity. [Abstract]2024 Jan 22;4(1):100673. PMID: 38171361 -
Eur J Pharm Biopharm
Interactions between mRNA lipid nanoparticles and immune cells in fresh human whole blood. [Abstract]2026 Jun 9:115146. PMID: 42264006 -
Solvent & Solubility
DMSO : 50 mg/mL (50.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Dong Y, Love KT, Dorkin JR, et al. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates [published correction appears in Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5753]. Proc Natl Acad Sci U S A. 2014;111(11):3955-3960. [Content Brief]
[2]. Oberli MA, Reichmuth AM, Dorkin JR, et al. Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy. Nano Lett. 2017;17(3):1326-1335. [Content Brief]
[3]. Hatit MZC, et al. Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles. Nat Nanotechnol. 2022 Mar;17(3):310-318. doi: 10.1038/s41565-021-01030-y. Epub 2022 Feb 7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.0064 mL | 5.0321 mL | 10.0642 mL | 25.1605 mL |
| 5 mM | 0.2013 mL | 1.0064 mL | 2.0128 mL | 5.0321 mL | |
| 10 mM | 0.1006 mL | 0.5032 mL | 1.0064 mL | 2.5161 mL | |
| 15 mM | 0.0671 mL | 0.3355 mL | 0.6709 mL | 1.6774 mL | |
| 20 mM | 0.0503 mL | 0.2516 mL | 0.5032 mL | 1.2580 mL | |
| 25 mM | 0.0403 mL | 0.2013 mL | 0.4026 mL | 1.0064 mL | |
| 30 mM | 0.0335 mL | 0.1677 mL | 0.3355 mL | 0.8387 mL | |
| 40 mM | 0.0252 mL | 0.1258 mL | 0.2516 mL | 0.6290 mL | |
| 50 mM | 0.0201 mL | 0.1006 mL | 0.2013 mL | 0.5032 mL |
CKK-E12 Related Classifications
HY-134781 Related Classifications
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