2. Peptides
  3. Peptide and Derivatives
  4. Peptides for Drug Delivery
  5. Cell-penetrating Peptides
  6. CPP12

CPP12 is a small, amphipathic, cyclic cell-penetrating peptide (CPP). CPP12 binds directly to plasma membrane phospholipids, enters mammalian cells via endocytosis, and then efficiently escapes from endosomes. CPP12 can be used for the intracellular delivery of drugs and chemical probes.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CPP12

CPP12 Chemical Structure

CAS No. : 1831064-62-0

Size Price Stock Quantity
1 mg In-stock
5 mg In-stock
10 mg In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of CPP12:

CPP12 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CPP12 is a small, amphipathic, cyclic cell-penetrating peptide (CPP). CPP12 binds directly to plasma membrane phospholipids, enters mammalian cells via endocytosis, and then efficiently escapes from endosomes. CPP12 can be used for the intracellular delivery of drugs and chemical probes[1].

In Vitro

CPP12 (5 μM; 2 h) exhibits high cytosolic entry efficiency in HeLa cells, serving as a 100% activity reference; its efficiency is reduced ~25-fold when serum concentration increases from 1% to 10% FBS[1].
CPP12 (5 μM; 2 h) enters HeLa cells primarily via endocytosis followed by endosomal escape[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CPP12 Related Antibodies
Molecular Weight

1244.45

Formula

C60H85N21O9
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Cyclo(Phe-{d-Phe}-{2-Nal}-Arg-{d-Arg}-Arg-{d-Arg}-Gln)
Sequence Shortening

Cyclo(F-{d-Phe}-{2-Nal}-R-{d-Arg}-R-{d-Arg}-Q)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (80.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8036 mL 4.0178 mL 8.0357 mL
5 mM 0.1607 mL 0.8036 mL 1.6071 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8036 mL 4.0178 mL 8.0357 mL 20.0892 mL
5 mM 0.1607 mL 0.8036 mL 1.6071 mL 4.0178 mL
10 mM 0.0804 mL 0.4018 mL 0.8036 mL 2.0089 mL
15 mM 0.0536 mL 0.2679 mL 0.5357 mL 1.3393 mL
20 mM 0.0402 mL 0.2009 mL 0.4018 mL 1.0045 mL
25 mM 0.0321 mL 0.1607 mL 0.3214 mL 0.8036 mL
30 mM 0.0268 mL 0.1339 mL 0.2679 mL 0.6696 mL
40 mM 0.0201 mL 0.1004 mL 0.2009 mL 0.5022 mL
50 mM 0.0161 mL 0.0804 mL 0.1607 mL 0.4018 mL
60 mM 0.0134 mL 0.0670 mL 0.1339 mL 0.3348 mL
80 mM 0.0100 mL 0.0502 mL 0.1004 mL 0.2511 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

CPP12 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CPP121831064-62-0CPP 12CPP-12Othersendosomal escapeFBSHeLa cellsendocytosisserum proteincell-penetrating agentInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CPP12
Cat. No.:
HY-P10649
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB) Italian - IT (251 KB) Korean - KR (251 KB) Portuguese - PT (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.