mPEG2000-DMPE
mPEG2000-DMPE is a pegylated lipid with a methyl group at the opposite end of the PEG chain, and can be used for the preparation of lipid nanoparticles or liposomes for targeted drug delivery applications. mPEG2000-DMPE is applicable for siRNA-related application studies targeting macrophages and dendritic cells.
For research use only. We do not sell to patients.
- CAS No.: 1254157-61-3
- Molecular Weight:2000 (Average)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Lipid nanoparticles containing mPEG2000-DMPE (6.25-50 nmol/L; 2 days) deliver CD45 siRNA to murine inflammatory peritoneal macrophages to induce dose-dependent knock-down of CD45 mRNA (up to 91% suppression) and protein (up to 56% suppression) in vitro[1].
Lipid nanoparticles containing mPEG2000-DMPE (50 nmol/L; 3 days) deliver CD45 siRNA to human monocyte-derived macrophages to induce 70% suppression of CD45 mRNA and 20% suppression of CD45 protein in vitro[1].
Lipid nanoparticles containing mPEG2000-DMPE (50 nmol/L; 3 days) deliver CD45 siRNA to human monocyte-derived dendritic cells to induce 50% suppression of CD45 mRNA and 30% suppression of CD45 protein in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1254157-61-3
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Molecular Weight 2000 (Average)
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SMILES
[H][C@@](COP(O)(OCCNC(OCCOCC)=O)=O)(OC(CCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
mPEG2000-DMPE Related Classifications
HY-W591332 Related Classifications
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