GalNAc-NAG37 phosphoramidite

Name: GalNAc-NAG37 phosphoramidite
Brand: MedChemExpress
SKU: HY-173247
Rating: 4.5 (1 reviews)

Cat. No.: HY-173247 Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
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GalNAc-NAG37 phosphoramidite is an N-acetylgalactosamine (GalNAc) derivative that acts as a ligand for the asialoglycoprotein receptor (ASGPR). GalNAc-NAG37 phosphoramidite can be used to synthesize GalNAc-siRNA and for oligonucleotide delivery.

For research use only. We do not sell to patients.

GalNAc-NAG37 phosphoramidite Chemical Structure

CAS No. : 2199491-27-3

Size	Stock	Quantity

Free Sample (0.1 - 0.2 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	Get quote
10 g	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vivo

GalNAc-NAG37 phosphoramidite (s.c.) delivers siRNA to mouse livers rapidly, with fluorescence signal accumulation observed in the liver, kidneys, and extrahepatic organs (spleen, uterus) post-subcutaneous administration, though liver signal intensity is lower than that of TG1-modified siRNA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1851.88

Formula

C₈₀H₁₂₇N₁₀O₃₇P

CAS No.

2199491-27-3

Appearance

Solid

Color

White to off-white

SMILES

CC(O[C@@H]1[C@H]([C@@H](O[C@@H]([C@@H]1OC(C)=O)COC(C)=O)OCCOCCNC([C@H](CCC(N[C@H](C(NCCOCCO[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)COC(C)=O)OC(C)=O)OC(C)=O)NC(C)=O)=O)CCC(NCCOCCO[C@H]3[C@@H]([C@H]([C@H]([C@H](O3)COC(C)=O)OC(C)=O)OC(C)=O)NC(C)=O)=O)=O)NC([C@@H]4CC[C@@H](CC4)OP(OCCC#N)N(C(C)C)C(C)C)=O)=O)NC(C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 70 mg/mL (37.80 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.5400 mL	2.7000 mL	5.3999 mL
5 mM	0.1080 mL	0.5400 mL	1.0800 mL
10 mM	0.0540 mL	0.2700 mL	0.5400 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.0%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (254 KB)

Handling Instructions (2659 KB)

References

[1]. Li Q, et al. Novel diamine-scaffold based N-acetylgalactosamine (GalNAc)-siRNA conjugate: synthesis and in vivo activities. RSC Adv. 2024;14(25):17461-17466. Published 2024 May 30. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.5400 mL	2.7000 mL	5.3999 mL	13.4998 mL
	5 mM	0.1080 mL	0.5400 mL	1.0800 mL	2.7000 mL
	10 mM	0.0540 mL	0.2700 mL	0.5400 mL	1.3500 mL
	15 mM	0.0360 mL	0.1800 mL	0.3600 mL	0.9000 mL
	20 mM	0.0270 mL	0.1350 mL	0.2700 mL	0.6750 mL
	25 mM	0.0216 mL	0.1080 mL	0.2160 mL	0.5400 mL
	30 mM	0.0180 mL	0.0900 mL	0.1800 mL	0.4500 mL